Limbic and HPA axis function in an animal model of chronic neuropathic pain

Physiology & Behavior
Yvonne M Ulrich-LaiJames P Herman

Abstract

Chronic pain can be considered a form of chronic stress, and chronic pain patients often have disturbances of the hypothalamic-pituitary-adrenal (HPA) axis, including abnormal cortisol levels. In addition, chronic pain patients have an increased incidence of depression and anxiety, stress-related disorders that are frequently accompanied by disturbances in the limbic system (e.g. hippocampus and amygdala) and the HPA axis. Despite the fact that the literature supports a strong link between chronic pain, stress disorders, and limbic dysfunction, the mechanisms underlying the effects of chronic pain on the HPA axis and limbic system are not understood. The current study employs a rodent neuropathic pain model (chronic constriction injury (CCI) of the sciatic nerve) to assess the long-term impact of chronic pain on the HPA axis and limbic system. Adult male rats received CCI or sham surgery; nociceptive behavioral testing confirmed CCI-induced neuropathic pain. Tests of HPA axis function at 13-23 days postsurgery demonstrated that CCI did not affect indices of basal or restraint stress-induced HPA axis activity. CCI increased the expression of corticotrophin releasing hormone mRNA in the central amygdala, and not the paraventricul...Continue Reading

References

Jun 1, 1991·The Clinical Journal of Pain·R H Dworkin, M J Gitlin
Apr 1, 1989·Neuroendocrinology·M Odio, A Brodish
Oct 1, 1986·Physiology & Behavior·J P Kroon, A L Riley
Feb 1, 1980·Physiology & Behavior·S R BurchfieldM S Elich
May 1, 1984·Pharmacology, Biochemistry, and Behavior·G J KantL E Jarrard
Jul 1, 1982·The Journal of Nervous and Mental Disease·D BlumerT Roth
Jul 1, 1994·Journal of Neuroscience Methods·S R ChaplanT L Yaksh
Jan 1, 1996·Critical Reviews in Neurobiology·J P HermanW E Cullinan
Apr 2, 1998·Physiology & Behavior·R J BlanchardD C Blanchard
Dec 17, 1998·The Journal of Endocrinology·L ArboreliusC B Nemeroff
Jan 29, 2000·Brain Research. Molecular Brain Research·L GivaloisL Tapia-Arancibia
Feb 25, 2000·Neuroendocrinology·Y M Ulrich-Lai, W C Engeland
Oct 12, 2000·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·F Holsboer
Mar 29, 2001·Biological Psychiatry·C M Pariante, A H Miller
Oct 2, 2001·Neuroscience Letters·A V ApkarianN M Szeverenyi
Nov 8, 2001·European Journal of Pharmacology·M Zimmermann
Nov 28, 2001·Journal of Neuroendocrinology·G Blackburn-Munro, R E Blackburn-Munro
Jul 5, 2002·Journal of Dental Research·A KorszunL Crofford
Oct 31, 2002·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Ania Korszun
Feb 11, 2003·Physiology & Behavior·Vesa K KontinenTheo F Meert
May 20, 2003·Journal of Neurochemistry·S D KuipersG J Ter Horst
May 22, 2003·Trends in Cognitive Sciences·Alexander PloghausDavid Borsook

❮ Previous
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Citations

Jun 7, 2007·Molecular Pain·Guangchen JiVolker Neugebauer
Oct 19, 2006·Chiropractic & Osteopathy·Katie Hardy, Henry Pollard
Apr 11, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yu Fu, Volker Neugebauer
Aug 26, 2014·Neuroscience and Biobehavioral Reviews·Ipek YalcinMichel Barrot
Jun 27, 2014·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·César Fernández-de-Las-PeñasJuan A Pareja
Oct 5, 2015·British Journal of Anaesthesia·A G BradburyR E Clutton
Dec 9, 2008·Brain Research·Catherine A MarcinkiewczRobert P Yezierski
Jul 8, 2008·Progress in Neurobiology·Nayef E Saadé, Suhayl J Jabbur
Jan 22, 2008·Hormones and Behavior·S L WalkerH Dobson
Sep 4, 2007·European Journal of Pharmacology·Daisuke KodamaMitsuo Tanabe
Dec 19, 2006·Physiology & Behavior·Hilary D WilsonPerry N Fuchs
Dec 23, 2006·Dental Clinics of North America·Ronald C Auvenshine
Jan 6, 2009·Annals of the New York Academy of Sciences·Ryan Jankord, James P Herman
Apr 14, 2016·Pain Research and Treatment·Natalie M WilsonFletcher A White
Jun 21, 2011·European Journal of Pain : EJP·T RouwetteT Kozicz
Feb 18, 2012·European Journal of Pain : EJP·T RouwetteK Vissers
Jan 13, 2011·Brain Research·Chiu-Wen ChouJianren Mao
Dec 1, 2014·Biological Psychiatry·Florent BarthasIpek Yalcin
Jan 1, 2013·Journal of Molecular Psychiatry·Pierre VeinanteMichel Barrot
Sep 23, 2014·Stress : the International Journal on the Biology of Stress·Bernadette E GraysonYvonne M Ulrich-Lai
Apr 11, 2015·Neuroscience and Biobehavioral Reviews·Victoria FasickTracey A Ignatowski
Apr 12, 2015·Brain Research Bulletin·Ildikó RáczAndreas Zimmer
Apr 14, 2009·Brain, Behavior, and Immunity·Jessica K AlexanderPhillip G Popovich
Jul 14, 2010·The Journal of Pain : Official Journal of the American Pain Society·Nora BourbiaAntti Pertovaara
Jul 11, 2014·Progress in Neurobiology·Elaine M JenningsDavid P Finn
Sep 6, 2011·Biological Psychiatry·Ipek YalcinMichel Barrot
Aug 14, 2010·Pain·Cheng-Hao TuJen-Chuen Hsieh
Oct 23, 2016·Archives of Oral Biology·Marcelo Ribeiro BergaminiCintia Helena Coury Saraceni
Mar 7, 2017·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Pere Boadas-VaelloEnrique Verdú
Sep 14, 2016·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Ted B Usdin, Eugene L Dimitrov
Jan 6, 2018·Pain Research & Management : the Journal of the Canadian Pain Society = Journal De La Société Canadienne Pour Le Traitement De La Douleur·Jeremy M Thompson, Volker Neugebauer
Aug 14, 2018·European Journal of Pain : EJP·David KangSylvia M Gustin

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