Limbic system structure volumes and associated neurocognitive functioning in former NFL players

Brain Imaging and Behavior
Christian LepageInga Katharina Koerte

Abstract

Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease associated with exposure to repetitive head impacts. CTE has been linked to disruptions in cognition, mood, and behavior. Unfortunately, the diagnosis of CTE can only be made post-mortem. Neuropathological evidence suggests limbic structures may provide an opportunity to characterize CTE in the living. Using 3 T magnetic resonance imaging, we compared select limbic brain regional volumes - the amygdala, hippocampus, and cingulate gyrus - between symptomatic former National Football League (NFL) players (n = 86) and controls (n = 22). Moreover, within the group of former NFL players, we examined the relationship between those limbic structures and neurobehavioral functioning (n = 75). The former NFL group comprised eighty-six men (mean age = 55.2 ± 8.0 years) with at least 12 years of organized football experience, at least 2 years of active participation in the NFL, and self-reported declines in cognition, mood, and behavior within the last 6 months. The control group consisted of men (mean age = 57.0 ± 6.6 years) with no history of contact-sport involvement or traumatic brain injury. All control participants provided neurobehavioral data. Compared to control...Continue Reading

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Citations

May 3, 2019·Journal of Neurotrauma·Sherveen N ParivashMichael Zeineh
Aug 3, 2020·Seminars in Neurology·Megan MarianiRobert A Stern
Aug 21, 2020·Seminars in Neurology·Orit H Lesman-SegevGil D Rabinovici
Oct 3, 2020·Journal of Neurotrauma·Benjamin L BrettTimothy B Meier
Jan 6, 2021·Journal of Neurotrauma·Timothy B MeierBenjamin L Brett
Apr 14, 2021·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Michael L AloscoJesse Mez
May 24, 2021·Acta Neuropathologica Communications·Breton M Asken, Gil D Rabinovici
Aug 14, 2021·Alzheimer's Research & Therapy·Michael L AloscoUNKNOWN DIAGNOSE CTE Research Project Investigators

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Methods Mentioned

BETA
PCA

Software Mentioned

Statistical Analysis System ( SAS
DETECT
FreeSurfer
Slicer
Syngo MR - B17

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