PMID: 6411793Jan 1, 1983Paper

Limitation of central vein thrombosis in total parenteral nutrition by continuous infusion of low-dose heparin

Journal of the American College of Nutrition
J ImperialG L Blackburn

Abstract

The use of continuous, low-dose heparin in total parenteral nutrition (TPN) formulas to limit central venous thrombosis was retrospectively evaluated. Seven of 129 patients (5.4%) developed central vein thrombosis when TPN solutions provided less than 6,000 units (usually 1,000 units/liter) heparin per day. In the subsequent period when heparin was increased to 6,000 units per day, 10 of 858 (less than 1.2%) patients developed a TPN-related thrombosis (P less than 0.0005). The incidence of antithrombin III (AT III) deficiency in a subset of high-risk patients scheduled to receive TPN was 51% (23 of 55). Twelve of the 23 had clinical evidence of thrombosis, whereas only 3 of 22 patients with normal AT III levels did (P less than 0.01) A major contributing factor to the development of thrombosis in TPN appears to be depression in antithrombin III levels, which is commonly found in patients who require this therapy. Low-dose heparin appears to reduce the incidence of thrombosis with TPN when provided continuously in sufficient amounts.

References

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Citations

Oct 2, 2007·The American Journal of Medicine·Angelia KirkpatrickGary Raskob
Nov 25, 2005·Cancer Investigation·Y S KuoGary L Goldberg
Apr 1, 1994·The British Journal of Surgery·L K Shanbhogue, J C Molenaar
Jan 1, 2008·JPEN. Journal of Parenteral and Enteral Nutrition·Vered KakzanovAnthony K C Chan
Sep 1, 1990·JPEN. Journal of Parenteral and Enteral Nutrition·T R BeersC R Fleming
Feb 18, 2014·JPEN. Journal of Parenteral and Enteral Nutrition·Joseph I BoullataUNKNOWN American Society for Parenteral and Enteral Nutrition
Sep 1, 1989·JPEN. Journal of Parenteral and Enteral Nutrition·M McMahonB R Bistrian
Nov 1, 1993·JPEN. Journal of Parenteral and Enteral Nutrition·R J MaillouxD F Kirby
Mar 1, 1987·The British Journal of Surgery·L K ShanbhogueB R Bistrian
Dec 1, 1995·Pediatric Pulmonology·M T DerishL R Frankel
Nov 28, 2001·Hematology·M E AndrewA K Chan
Mar 10, 2001·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·J P TraynorR A Mactier
Dec 1, 2004·JPEN. Journal of Parenteral and Enteral Nutrition·Murray Bern
Mar 1, 1991·DICP : the Annals of Pharmacotherapy·D F DriscollB R Bistrian
Oct 1, 1996·The Surgical Clinics of North America·M M Meguid, A C Campos

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