PMID: 7016150May 1, 1981Paper

Limitation of myocardial infarct size in patients less than 66 years treated with alprenolol

British Heart Journal
J H JürgensenO Pedersen-Bjergaard

Abstract

Two hundred and eighty-two patients less than 66 years of age admitted with suspected or definite myocardial infarction were allocated in a random fashion to treatment with alprenolol or placebo. Treatment was started immediately upon admission with 5-10 mg alprenolol or placebo intravenously, followed by 200 mg alprenolol or placebo orally twice a day for one year. In 178 patients a definite myocardial infarction was diagnosed. Myocardial infarct size could be estimated from serial determinations of serum total creatine kinase in 42 patients treated with alprenolol and 43 patients receiving placebos. Median infarct size was 20.6 CK g Eq/m2 body surface in the alprenolol group, the corresponding figure in the placebo group being 34.4 CK g Eq/m2 body surface. Median rate of release of creatine kinase from the ischaemic myocardium was 27.7 U/1 per hour and 48.0 U/1 per hour after alprenolol and placebo, respectively. Alprenolol limited infarct size significantly provided the treatment was started within 12 hours of the onset of symptoms.

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Citations

Oct 14, 1983·European Journal of Pharmacology·V S MurthyD H Schmidt
Aug 19, 1982·The New England Journal of Medicine·R M Norris
Jan 5, 1984·The New England Journal of Medicine·UNKNOWN International Collaborative Study Group
Mar 1, 1983·British Heart Journal·D M BoyleR G Shanks
Mar 1, 1985·Progress in Cardiovascular Diseases·S YusufP Sleight
Jan 1, 1983·The American Journal of Medicine·E BraunwaldP R Maroko
Mar 1, 1982·Journal of Clinical and Hospital Pharmacy·D M Burley
Jul 1, 1983·British Journal of Clinical Pharmacology·H J JürgensenU Brodthagen
Jan 1, 1987·Progress in Cardiovascular Diseases·L M Buja, J T Willerson
Oct 23, 1985·The American Journal of Cardiology·R A KlonerE Braunwald
Jan 1, 1986·British Journal of Clinical Pharmacology·B N Prichard, C W Owens
Jan 1, 1988·Pharmacotherapy·V S Murthy, W H Frishman
Jan 1, 1981·Acta Medica Scandinavica. Supplementum·J K KjekshusR Hol
Aug 10, 2000·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·V PiriouJ J Lehot

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