Limitations in the use of rifampicin-gelatin grafts against virulent organisms

Journal of Vascular Surgery
Susumu KoshikoMasashi Inaba

Abstract

Efficacy and duration of antibacterial activity of rifampicin-gelatin grafts against virulent organisms were evaluated in an animal model. Rifampicin-gelatin grafts were prepared with impregnation of Gelseal (Vascutek Ltd, Scotland) graft in 1 mg/mL rifampicin solution. Rifampicin-gelatin grafts (6 cm long; n = 24) and plain Gelseal grafts as controls (n = 4) were implanted into the canine abdominal aorta with inoculation of Staphylococcus epidermidis, Escherichia coli, or methicillin-resistant Staphylococcus aureus (MRSA), and the rifampicin-gelatin grafts were retrieved after 1 to 4 weeks. Disks cut from the retrieved rifampicin-gelatin grafts were placed on agar plates streaked with one of the organisms, and the graft antibacterial activity was assessed with the width of the inhibition zone. In in vitro tests, initial inhibition zones (inhibition zone of 24 hours after incubation) of rifampicin-gelatin grafts against S epidermidis, MRSA, and E coli were 40.0 +/- 0.3 mm, 36.0 +/- 0.2 mm, and 11.8 +/- 0.1 mm, respectively. In the implantation, S epidermidis -inoculated rifampicin-gelatin grafts had no findings of graft infection, and no colony growth was recognized on the plates streaked with the perigraft fluids. Initial inhi...Continue Reading

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Citations

Dec 13, 2012·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Satoshi YamashiroYukio Kuniyoshi
Apr 3, 2010·Interactive Cardiovascular and Thoracic Surgery·Manabu MorishimaRyuzo Sakata
Apr 5, 2014·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Katsuhiro YamanakaYutaka Okita
Aug 18, 2004·The Journal of Surgical Research·Masanori FujitaTadaaki Maehara
Jul 11, 2006·Journal of Vascular Surgery·Stephen O'ConnorJean Pierre Becquemin
Mar 29, 2005·Asian Cardiovascular & Thoracic Annals·Yukio KuniyoshiKatuya Arakaki
Jun 5, 2012·Vascular·Michel BattUNKNOWN Association Universitaire de Recherche en Chirurgie Vasculaire (AURC)
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Apr 25, 2012·Journal of Biomedical Materials Research. Part a·Achala de MelAlexander M Seifalian
Sep 5, 2020·CVIR Endovascular·Kei KazunoSeiichiro Murata
Jul 6, 2014·General Thoracic and Cardiovascular Surgery·Taijiro SuedaKatsuhiko Imai
Sep 9, 2004·Surgical Infections·Michelle D Taylor, Lena M Napolitano
Feb 10, 2020·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·Nabil ChakféAnders Wanhainen
Oct 8, 2018·Journal of Vascular Surgery·Nicholas J MaddenDouglas A Troutman
Apr 13, 2021·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·Hozan MuftyInge Fourneau
Feb 14, 2012·Current Problems in Surgery·R James Valentine, Jayer Chung

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