Limitations of EBV-PCR monitoring to detect EBV associated post-transplant lymphoproliferative disorder

Pediatric Transplantation
David A AxelrodJohn C Magee

Abstract

Post-transplant lymphoproliferative disorder (PTLD) represents a significant threat to the survival of pediatric transplant recipients. Epstein-Barr (EBV) viral load monitoring using polymerase chain reaction (PCR) has been reported to have a variable sensitively with relatively higher specificity as in an indicator of the development of PTLD. We report two cases of pathologically confirmed PTLD in children who failed to develop sustained increases in their EBV-PCR determined viral loads. We suggest that clinicians should be aware of the potential for false-negative results of EBV-PCR in pediatric transplant recipients.

References

Feb 12, 1999·Transplantation·R ShapiroT E Starzl
Dec 22, 1999·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·T SrivastavaB A Warady
Feb 3, 2000·Journal of Clinical Microbiology·H G NiestersA D Osterhaus
Jun 9, 2001·Transplant Infectious Disease : an Official Journal of the Transplantation Society·D T RoweM Green
Jun 9, 2001·Transplant Infectious Disease : an Official Journal of the Transplantation Society·M A Nalesnik
Jul 27, 2001·Pediatric Transplantation·M H CollinsJ E Tomaszewski
Nov 28, 2002·Pediatric Transplantation·R D Holmes, R J Sokol

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Citations

Oct 9, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jutta K Preiksaitis
Oct 9, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Britta HöckerBurkhard Tönshoff
Jan 1, 2008·Expert Opinion on Medical Diagnostics·Steven Ft Thijsen, Marjolein Pd Deege
Jul 29, 2008·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Patrick GarceauMario Sénéchal
Apr 16, 2008·The Journal of Pediatrics·Agnieszka KulikowskaCharles E Canter
Dec 27, 2005·Clinics in Liver Disease·Greg Tiao, Frederick C Ryckman
Aug 16, 2005·British Journal of Haematology·Ross Pinkerton
Apr 28, 2005·Periodontology 2000·Jørgen Slots
Mar 11, 2004·Pediatric Transplantation·Vikas R DharnidharkaRobert S Fennell
Feb 13, 2007·Transplant International : Official Journal of the European Society for Organ Transplantation·Nicolaas A BakkerWillem J van Son
Jan 16, 2009·Pediatrics International : Official Journal of the Japan Pediatric Society·Tetsuya SatoHiroshi Wakiguchi
Jan 31, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J K PreiksaitisUNKNOWN American Society of Transplantation Infectious Diseases Community of Practice
Jul 29, 2008·Transplant Infectious Disease : an Official Journal of the Transplantation Society·D D HenryV R Dharnidharka
Apr 16, 2011·Pediatric Transplantation·Eriko TanakaMikiya Fujieda
Dec 25, 2009·Transplant Infectious Disease : an Official Journal of the Transplantation Society·F CalabreseF Rea
Dec 21, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Christian BendenMartin J Elliott
Nov 1, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Britta MaeckerChristoph Klein
Jun 1, 2004·Inflammatory Bowel Diseases·Didier ReijasseLaurent Beaugerie
Aug 12, 2009·International Journal of Hematology·Hideaki OhtaKeiichi Ozono
Nov 10, 2013·Transplantation·Sam N SherstonKathryn J Wood
Dec 17, 2004·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Tahar HadouAlain Le Faou

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