Limitations of follicle-stimulating hormone in assessing menopause status: findings from the National Health and Nutrition Examination Survey (NHANES 1999-2000)*

Menopause : the Journal of the North American Menopause Society
Janet B HenrichLester R Curtin

Abstract

We used data from the National Health and Nutrition Examination Survey (NHANES 1999-2000) to: establish new population-based estimates for follicle-stimulating hormone (FSH) and luteinizing hormone (LH); identify factors associated with FSH; and assess its efficacy in distinguishing among women in the reproductive, menopause transition, and postmenopausal stages. Nationally representative sample of 576 women aged 35 to 60 years examined during NHANES 1999-2000. Levels of FSH and LH increased significantly with reproductive stage. (Geometric mean FSH levels for successive stages: reproductive, 7.0 mIU/mL, SE 0.4; menopause transition, 21.9 mIU/mL, SE 3.7; and postmenopause, 45.7 mIU/mL, SE 4.3). There was considerable overlap, however, among distributions of FSH by stage. Only age and reproductive stage were significantly associated with FSH in multivariable analysis. FSH cutoff points between the reproductive and menopause transition stages [FSH = 13 mIU/mL, sensitivity 67.4% (95% CI 50.0-81.1), specificity 88.1% (95% CI 81.1-92.8)] and between the menopause transition and postmenopause stages [FSH = 45 mIU/mL, sensitivity 73.6% (95% CI 60.1-83.7), specificity 70.6% (95% CI 52.4-84.0)] were neither sensitive nor very specific. ...Continue Reading

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Citations

Apr 29, 2006·Menopause : the Journal of the North American Menopause Society·Nanette Santoro
Jul 16, 2008·Menopause : the Journal of the North American Menopause Society·Lora E FlemingDavid J Lee
Dec 12, 2012·Climacteric : the Journal of the International Menopause Society·M WiacekH-J Kim
Feb 7, 2013·Journal of Vascular and Interventional Radiology : JVIR·Geoffrey R Kaump, James B Spies
Nov 28, 2008·The Breast : Official Journal of the European Society of Mastology·Olaf OrtmannHans Wildiers
Aug 8, 2007·Fertility and Sterility·Siobán D HarlowUNKNOWN ReSTAGE Collaboration
Jul 10, 2009·American Journal of Primatology·S Atsalis, E N Videan
Dec 11, 2008·American Journal of Primatology·Sylvia Atsalis, Elaine Videan
Feb 7, 2012·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Maryam S HamidiAngela M Cheung
May 17, 2012·Clinical Endocrinology·Melanie C Davies, Beth Cartwright
Apr 13, 2007·Biology of Reproduction·K P JonesK Hawkes
Apr 2, 2009·Environmental Health Perspectives·Joanna M GaitensPeter J Ashley
Jan 9, 2018·International Journal of Radiation Biology·Eric J GrantKei Nakachi
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Apr 9, 2017·Annals of Clinical Biochemistry·Melanie DaviesMary Ann Lumsden
Apr 20, 2021·Gynécologie, Obstétrique, Fertilité & Sénologie·C Rousset-Jablonski

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