PMID: 9423950Jan 10, 1998Paper

Limitations of intra-arterial thrombolysis

Cardiovascular Surgery : Official Journal of the International Society for Cardiovascular Surgery
M J RickardM Appleberg

Abstract

The purpose of this study was to assess the efficacy, costs and complications of acutely ischaemic limbs initially treated with urokinase-induced thrombolysis, and to compare the subsequent patencies of occluded native arteries, vein grafts and prosthetic grafts. Data from 45 consecutive episodes of thrombolysis in 37 patients (37 limbs) were reviewed retrospectively. An initial bolus dose of urokinase was used in all limbs, with pulse-spray in nine 30 limbs received additional infusions of urokinase including six who received initial treatment with pulse-spray. Percutaneous transluminal angioplasty or surgical intervention was undertaken at any stage when considered appropriate. There were 14 occluded native arteries (31%), 12 vein grafts (27%), 16 prosthetic polytetrafluoroethylene grafts (35%), and three composite grafts (7%). Thrombolysis was initially successful in 33 episodes (73%). Of these, no additional procedure was required in three, percutaneous transluminal angioplasty in 23, other surgery in 11 and bypass surgery in seven with more than one additional procedure being undertaken in 10. Of the 12 episodes with initial failure, major surgery was performed in eight and no procedure in four. Lysis-related complications...Continue Reading

Citations

Jul 28, 2010·Cardiovascular and Interventional Radiology·Stefan Müller-HülsbeckThomas Jahnke
Mar 1, 2008·Seminars in Interventional Radiology·Martin G Radvany, Michael Wholey
Dec 6, 2012·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Thomas ZellerDierk Scheinert
Sep 10, 2013·Annals of Vascular Surgery·Damir VakhitovJuha-Pekka Salenius
Dec 23, 2011·Annals of Vascular Surgery·Christian Ochoa, Fred A Weaver
May 10, 2011·Techniques in Vascular and Interventional Radiology·Michael Wholey
Feb 4, 2010·Techniques in Vascular and Interventional Radiology·Robert A Lookstein, Sara Lewis
Dec 5, 2008·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·G PlateJ Lanke
Jun 21, 2006·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Dimitris KarnabatidisDimitris Siablis
Oct 8, 2013·Vascular Medicine·Yabiz SedghiChristopher J White
Apr 17, 2012·Vascular and Endovascular Surgery·Giovanni BrancaccioGiovanni Maria Celoria
Oct 31, 2007·Circulation·Jason H Rogers, John R Laird
Jul 1, 2009·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Stefan Müller-HülsbeckThomas Jahnke
Sep 1, 1999·Current Opinion in Hematology·C K Shortell, C W Francis
Jan 29, 2005·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Michael H WholeyDonald Joiner

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