PMID: 6162569Jan 1, 1980Paper

Limitations of post-extrasystolic potentiation in assessing regional myocardial viability in man

Catheterization and Cardiovascular Diagnosis
J D SlackW O'Connor

Abstract

To investigate the usefulness of regional response to post-extrasystolic potentiation as a predictor of left ventricular viability in patients with coronary artery disease, 46 patients underwent calibrated biplane left ventricular cineangiography during which a single, timed ventricular premature contraction was introduced. Of 758 normal or hypokinetic segments, 486 (64.1%) showed a positive response to post-extrasystolic potentiation. Of 116 akinetic or dyskinetic segments, only 51 (43.9%) showed a positive response to post-extrasystolic potentiation (P less than 0.001). Because akinetic or dyskinetic areas would not be expected to respond to post-extrasystolic potentiation based on animal laboratory data, alternative explanations were sought to explain such positive response in man. Analysis of percent change in chord length of normal or hypokinetic segments adjacent to akinetic or dyskinetic segments that did or did not respond to post-extrasystolic potentiation revealed (10.2% +/- 1.2%) vs (1.3% +/- 0.7%) improvement, respectively (P less than 0.001) (mean +/- SE). Passive rather than active events may be responsible for "improved" regional wall motion following post-extrasystolic potentiation in akinetic or dyskinetic regi...Continue Reading

References

Oct 1, 1977·Annals of Internal Medicine·R H HelfantV S Banka
May 1, 1979·The American Journal of Cardiology·J H KleimanE B Stinson
Nov 1, 1978·The American Journal of Cardiology·W SullivanJ E Edwards
Jan 1, 1976·Catheterization and Cardiovascular Diagnosis·J S ColeD H Glaeser
May 1, 1975·The American Journal of Cardiology·M M BodenheimerR H Helfant
Jan 1, 1974·The American Journal of Cardiology·P F CohnM V Herman
Mar 1, 1971·Progress in Cardiovascular Diseases·W A Baxley, T J Reeves

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Citations

Feb 1, 1986·American Heart Journal·M W CooperR M Lust

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