PMID: 8971885Dec 1, 1996Paper

Limitations to body length/serum creatinine ratio as an estimate of glomerular filtration in children

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
M G SeikalyB S Arant

Abstract

The ability of the Schwartz formula (CSCH) to estimate glomerular filtration rate (GFR) accurately was investigated in children with renal disease. 125Iodine-iothalamate clearance (CIO) was used as the reference standard for measuring GFR. Data from 176 CIO studies performed on 133 children (aged between 1 and 18 years) were compared with the simultaneous estimation of GFR by CSCH. The overestimation of GFR by CSCH was inversely proportional to the level of renal function. When CIO was > 90 ml/min per 1.73 m2, CSCH overestimated GFR by only 0.1% +/- 3%, but when CIO was < or = 15 ml/min per 1.73 m2, CSCH overestimated GFR by 164% +/- 42%. When renal function is normal or mildly reduced (GFR > 50 ml/min per 1.73 m2), CSCH overestimated CIO by only 10.3 +/- 3.0%, compared with 90.3 +/- 14.5% when renal function was moderately to severely curtailed (GFR < or = 50 ml/min per 1.73 m2). We conclude that CSCH is valid in predicting GFR only in children with normal renal function and mild insufficiency.

Citations

Mar 18, 2005·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Mouin G SeikalyRichard Browne
Nov 23, 2006·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Michael ZappitelliGilles Paradis
Oct 8, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Trine Borup AndersenJens Brøchner-Mortensen
Dec 2, 2009·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Amina BenlamriGuido Filler
Feb 1, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Joanna StefanowiczAnna Balcerska
Mar 12, 2004·Nephrology·Prayong VachvanichsanongAlan Geater
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Apr 1, 2011·Transplantation·Jesper M KiveläJouni Lauronen
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Jul 4, 2015·Clinical Pharmacokinetics·Frederique RodieuxMarc Pfister
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