Limited airway effects in mild asthmatics after exposure to air pollution in a road tunnel

Respiratory Medicine
Britt-Marie LarssonM Svartengren

Abstract

Ambient air pollution is a contributing factor to respiratory morbidity and mortality and asthmatics are a particularly vulnerable population. The aim of the study was to investigate whether acute exposure to traffic related air pollution in a road tunnel would increase bronchial responsiveness in mild asthmatics, and if this would be accompanied by increased measures of inflammatory markers in the airways assessed by nasal lavage (NAL) and induced sputum. Fourteen mild asthmatics (7 treated with inhaled corticosteroids) were exposed for 2 h in a road tunnel and a control environment, respectively, separated by at least 3 weeks. Symptoms and peak expiratory flow (PEF) were recorded. Seven hours following exposure sessions, subjects underwent measurements of fraction of exhaled nitric oxide (FENO), spirometry, and a bronchial provocation test. NAL, induced sputum and blood samples were collected. The median PM(2.5) and PM(10) levels during the exposure occasions in the road tunnel were 80 (range 41-93) μg/m(3) and 183 (72-213) μg/m(3) respectively. Irritative symptoms from the airways increased and PEF decreased after road tunnel exposure. Increased levels of IL-10, IL-12 and TNF-α were observed in NAL fluid from subjects withou...Continue Reading

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Citations

Oct 11, 2012·Bioanalysis·Stuart SnowdenCraig E Wheelock
Dec 6, 2014·Mutation Research. Reviews in Mutation Research·Peter MøllerSteffen Loft
Jun 29, 2011·Environmental Health Perspectives·Sandrah P EckelFrank D Gilliland
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Oct 15, 2011·Respiratory Medicine·Anna Klepczyńska-NyströmMagnus Svartengren
Jan 22, 2015·Journal of Exposure Science & Environmental Epidemiology·Jaime Mirowsky, Terry Gordon
Apr 22, 2014·Environmental Health Perspectives·Véronique EzrattyMichel Aubier
Jan 14, 2011·Epidemiology·Moniek ZuurbierBert Brunekreef
Nov 12, 2013·Epidemiology·Lars ModigAnna-Carin Olin
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Dec 5, 2020·Environmental Health Perspectives·Sabrina EdwardsXiaoquan Rao
Feb 2, 2021·Environmental Health Perspectives·Florencia Pascual

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