Limited beneficial effects of piceatannol supplementation on obesity complications in the obese Zucker rat: gut microbiota, metabolic, endocrine, and cardiac aspects

Journal of Physiology and Biochemistry
Elizabeth HijonaC Carpene

Abstract

Resveratrol is beneficial in obese and diabetic rodents. However, its low bioavailability raises questions about its therapeutic relevance for treating or preventing obesity complications. In this context, many related natural polyphenols are being tested for their putative antidiabetic and anti-obesity effects. This prompted us to study the influence of piceatannol, a polyhydroxylated stilbene, on the prevention of obesity complications in Zucker obese rats. A 6-week supplementation was followed by the determination of various markers in plasma, liver, adipose tissue and heart, together with a large-scale analysis of gut microbiota composition. When given in doses of 15 or 45 mg/kg body weight/day, piceatannol did not reduce either hyperphagia or fat accumulation. It did not modify the profusion of the most abundant phyla in gut, though slight changes were observed in the abundance of several Lactobacillus, Clostridium, and Bacteroides species belonging to Firmicutes and Bacteroidetes. This was accompanied by a tendency to reduce plasma lipopolysaccharides by 30 %, and by a decrease of circulating non-esterified fatty acids, LDL-cholesterol, and lactate. While piceatannol tended to improve lipid handling, it did not mitigate h...Continue Reading

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Citations

Oct 30, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yen-Chen TungMin-Hsiung Pan
Apr 8, 2017·Journal of Medicinal Food·Jonathan Kershaw, Kee-Hong Kim
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May 1, 2021·International Journal of Molecular Sciences·Kamila Kasprzak-DrozdAnna Oniszczuk
Nov 4, 2021·Journal of the Academy of Nutrition and Dietetics·Vivien W FamRobert M Hackman

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