PMID: 10738212Mar 30, 2000Paper

Limited but definite efficacy of prophylactic hepatic arterial infusion chemotherapy after curative resection of colorectal liver metastases: A randomized study

Cancer
T TonoN Kikkawa

Abstract

Greater than 50% of patients who undergo curative resection of liver metastases from colorectal carcinoma develop recurrent disease in the residual liver. Although several studies have attempted to use hepatic arterial infusion (HAI) chemotherapy to prevent recurrence, to the authors' knowledge the efficacy of the treatment has not yet been determined. Nineteen patients who underwent curative hepatectomy for metastatic colorectal carcinoma randomly were assigned into the HAI group (nine patients) or the control group (ten patients). Patients in the HAI group received continuous intraarterial infusion of 5-fluorouracil (5-FU) (500 mg/day) for 4 days followed by a 3-day rest. The treatment was continued for 6 weeks. The median follow-up period was 62.2 months. The recurrence was confirmed in three patients in the HAI group and in eight patients in the control group. Of these, recurrence in the remnant liver was observed in one patient and in six patients, respectively. The median disease free interval after hepatectomy was 62.6 months in the HAI group and 13.8 months in the control group. The 1-year, 2-year, and 3-year disease free survival rates were 77.8%, 77.8%, and 66.7%, respectively, in the HAI group and 50.0%, 30.0%, and 2...Continue Reading

Citations

Apr 13, 2007·Expert Review of Anticancer Therapy·Ami Sabharwal, David Kerr
Jun 9, 2006·Expert Review of Anticancer Therapy·Thomas J VoglMohamed Nabil
Jul 25, 2008·Clinical Colorectal Cancer·Derek G PowerNancy E Kemeny
Apr 9, 2008·Seminars in Oncology·Cletus A Arciero, Elin R Sigurdson
Mar 15, 2008·Cancer·Dan S Zuckerman, Jeffrey W Clark
Jul 4, 2007·Surgical Oncology Clinics of North America·Lawrence Leichman
Apr 21, 2010·The Cancer Journal·Margaret K Callahan, Nancy E Kemeny
Jul 11, 2019·The Cochrane Database of Systematic Reviews·Malgorzata M BalaJos Kleijnen

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