Limited but significant protective effect of hypothermia on ultra-early-type ischemic neuronal injury in the thalamus

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
K KawaiA Tamura

Abstract

We investigated the protective effect of hypothermia on ultra-early-type ischemic injury in the thalamic reticular nucleus of the rat. Cerebral ischemia was produced by 5 min of cardiac arrest followed by resuscitation. Rectal and cranial temperature during and after cardiac arrest was maintained at 37-38 degrees C in the normothermic group and at 32-33 degrees C in the hypothermic group. In the postischemic hypothermic group, temperature was maintained at 32-33 degrees C starting 15 min after normothermic ischemia. Histological damage was evaluated quantitatively. While after 5 min of recirculation there was no difference in morphological changes in terms of neuronal halo formation, intraischemic hypothermia reduced the severity of the degenerative changes represented by vacuolated or dark neurons by 15 min. Postischemic hypothermia failed to show any evidence of protection by 30 min. The protective effect of intraischemic hypothermia remained significant when evaluated at 14 days after ischemia by volumetry of the lesion and neuronal density analysis, whereas postischemic hypothermia had no clear protective effect. These results suggest that the protective effect of intraischemic hypothermia applies to neurons susceptible to ...Continue Reading

References

Mar 11, 1992·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K KawaiI Klatzo
Jul 1, 1991·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·F A Welsh, V A Harris
Sep 1, 1990·Journal of Neuropathology and Experimental Neurology·W D DietrichI Valdes
May 1, 1990·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·H MinamisawaB K Siesjö
Jul 1, 1990·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·F A WelshV A Harris
Jul 1, 1989·Stroke; a Journal of Cerebral Circulation·R BustoM D Ginsberg
Jul 1, 1988·Physiological Reviews·M Steriade, R R Llinás
Oct 1, 1988·Stroke; a Journal of Cerebral Circulation·M SeidaI Klatzo
Dec 1, 1987·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R BustoM D Ginsberg
Sep 1, 1985·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·P Blomqvist, T Wieloch
Jul 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·F Crick
Jun 1, 1993·Trends in Neurosciences·J Mitrofanis, R W Guillery
Mar 1, 1995·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K KawaiI Klatzo
Oct 29, 1993·Science·M SteriadeT J Sejnowski
Jul 1, 1993·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·W D DietrichM D Ginsberg
Jul 1, 1993·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·D T Ross, D I Graham
May 1, 1993·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K HiramatsuK S Lee

❮ Previous
Next ❯

Citations

Jan 14, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·N KawaiR F Keep

❮ Previous
Next ❯

Methods Mentioned

BETA
light microscopy

Related Concepts

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.