Limited flow cytometry panels on bone marrow specimens reduce costs and predict negative cytogenetics

American Journal of Clinical Pathology
Douglas G Hoffmann, Burton H Kim

Abstract

To determine the clinical and financial impact and predictive value of a limited flow cytometry strategy in the evaluation of bone marrow specimens. Consecutive bone marrow cases (n = 1,242) were reviewed following the independent, prospective application of two flow cytometry protocols: a limited marker strategy and a multimarker strategy. Combined morphologic and flow cytometry findings were also compared with cytogenetic results. A limited flow cytometry strategy did not have a negative impact on disease detection and resulted in reduced utilization and cost. In addition, negative combined morphology and flow cytometry had a 98.4% predictive value for negative cytogenetics (P < .001). Careful initial evaluation of bone marrow specimens can markedly reduce the costs of bone marrow examination and significantly reduce the need for flow cytometric and cytogenetic studies on these samples.

References

Apr 17, 2010·American Journal of Clinical Pathology·Derek K MarseeDavid M Dorfman
Jul 31, 2010·International Journal of Laboratory Hematology·J Hall, Kathryn Foucar
Feb 18, 2012·American Journal of Clinical Pathology·Elisa CannizzoFrederic Preffer

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Citations

Oct 15, 2019·American Journal of Clinical Pathology·Estafani RivasWei Cui

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