Limited genetic control of specific IgE responses to rye grass pollen allergens in Australian twins

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
R SluyterW J Britton

Abstract

Both genetic and environmental factors are thought to contribute to specific IgE responses, however, the relative contribution of each in the responses to individual ryegrass pollen allergens is largely unknown even though some responses to allergens have been linked to certain HLA complexes. Using a large group of monozygotic and dizygotic twins, this study was designed to investigate the IgE binding profiles of individual ryegrass pollen (Lolium perenne) components to assess the relative contribution of genetic and environmental factors in determining IgE responses to specific allergens. Ryegrass pollen proteins were separated by electrophoresis and immunoblotted with sera from 191 pairs of twins where at least one sibling had a SPT > 2 mm to perennial ryegrass. Concordance levels for individual ryegrass pollen components were compared between monozygotic and dizygotic twins in a subset group where both twins had SPT > 3 mm to perennial ryegrass. Immunoblotting revealed 23 individual IgE-binding components from ryegrass pollen. Although there was a significantly greater proportion of monozygotic twins with SPT wheals greater than 3 mm when compared with the dizygotic twins, the mean case-wise concordance for the immunoblot co...Continue Reading

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Citations

Mar 26, 2008·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Simon Francis ThomsenVibeke Backer
Feb 26, 2000·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·L GrayA J Woolcock
Sep 11, 2002·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C KarihalooW J Britton
Mar 24, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·X LiuX Wang
Nov 7, 2006·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·P N Le Souëf
Nov 1, 2006·Allergology International : Official Journal of the Japanese Society of Allergology·Brett James GreenEuan Roger Tovey
Mar 11, 2003·Clinical and Diagnostic Laboratory Immunology·Yee-Hsuan ChiouShiao-ping Huang
Mar 9, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ronald SluyterJames S Wiley

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