Limited Predictive Value of Serum Inflammatory Markers for Diagnosing Fracture-Related Infections: results of a large retrospective multicenter cohort study

Journal of Bone and Joint Infection
P BoschG A M Govaert

Abstract

Introduction: Diagnosing Fracture-Related Infections (FRI) based on clinical symptoms alone can be challenging and additional diagnostic tools such as serum inflammatory markers are often utilized. The aims of this study were 1) to determine the individual diagnostic performance of three commonly used serum inflammatory markers: C-Reactive Protein (CRP), Leukocyte Count (LC) and Erythrocyte Sedimentation Rate (ESR), and 2) to determine the diagnostic performance of a combination of these markers, and the additional value of including clinical parameters predictive of FRI. Methods: This cohort study included patients who presented with a suspected FRI at two participating level I academic trauma centers between February 1st 2009 and December 31st 2017. The parameters CRP, LC and ESR, determined at diagnostic work-up of the suspected FRI, were retrieved from hospital records. The gold standard for diagnosing or ruling out FRI was defined as: positive microbiology results of surgically obtained tissue samples, or absence of FRI at a clinical follow-up of at least six months. The diagnostic accuracy of the individual serum inflammatory markers was assessed. Analyses were done with both dichotomized values using hospital thresholds ...Continue Reading

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Oct 11, 2019·American Journal of Clinical Pathology·Ivana LapićMario Plebani
Jul 1, 2020·The Bone & Joint Journal·Irene K SigmundMartin A McNally
Feb 14, 2019·Journal of Bone and Joint Infection·Niels van der NaaldDetlef van der Velde
Apr 24, 2019·Journal of Bone and Joint Infection·Noam ShohatJavad Parvizi
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Mar 23, 2020·OTA International : the Open Access Journal of Orthopaedic Trauma·David J Hak
May 6, 2021·BMC Musculoskeletal Disorders·Cheng LiCristina Ojeda-Thies

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Methods Mentioned

BETA
amputation
ESR
light scattering

Software Mentioned

Statistical Package for Social Sciences ( SPSS® )

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