Limited prognostic value of myocardial viability assessment in patients with coronary artery diseases and severe left ventricular dysfunction

Journal of Thoracic Disease
Yihua LiuNianguo Dong

Abstract

Myocardial viability assessment is typically performed in patients with coronary artery disease (CAD) and severe left ventricular (LV) dysfunction to identify those who might benefit from revascularization and assist in decision making process. However, the prognostic value of myocardial viability testing remains a debating issue. Positron Emission Tomography using 18F-fluorodeoxyglucose (18FDG-PET) was performed in 81 patients with ischemic LV dysfunction [ejection fraction (EF) ≤35%] for myocardial viability assessment prior to coronary artery bypass surgery. Fifty-three of them received finally coronary artery bypass grafting and were divided into two groups according to the extent of myocardial scar: one group with scar burden ≥10% (n=30) and the other with scar burden <10% (n=23). The remaining patients were contraindicated for CABG and received optimal medical treatment (OMT, n=28). All patients were followed up and the primary endpoint was all-cause mortality and the secondary endpoint was a composite of all-cause mortality and major adverse cardiovascular and cerebrovascular events (MACCE). 18FDG-PET revealed a different profile of myocardial viability among three groups with respect to the extent of myocardial scar, th...Continue Reading

Citations

Jul 2, 2019·Current Opinion in Cardiology·Abhishek Khemka, Stephen G Sawada
Jul 10, 2021·Journal of the American College of Cardiology·Torsten DoenstMario Gaudino

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