Limited prognostic value of preoperative circulating tumor cells for early biochemical recurrence in patients with localized prostate cancer

Urologic Oncology
Christian P MeyerThomas Steuber

Abstract

The presence of circulating tumor cells (CTCs) is an established marker for prognosis in men with castration-resistant prostate cancer. A cutoff of ≥5 CTCs/7.5ml blood in the CellSearch Epithelial Cell Test has been shown to stratify prognostic groups and predict outcome of abiraterone treatment. In contrast, the value of CTC detection in men with localized prostrate cancer before radical prostatectomy (RP) is unknown. A total of 152 patients treated with RP between 06/2009 and 09/2009 were included. Peripheral venous blood drawn the day before RP was evaluated for CTCs by the CellSearch system. The detection of CTCs was correlated with prostate-specific antigen (PSA) and the histopathological outcome of the RP specimen. A cutoff of 0 vs. ≥1 CTC/7.5ml blood was defined as the threshold for positive vs. negative CTC status. Median age was 62 years and median PSA was 6.7ng/dl. Staging revealed 62.5% pT2, 26.3% pT3a, and 11.2% pT3b tumors, and high-grade disease (≥Gleason 4+3) was determined in 25.6% of patients. CTCs were detected in 17 patients (11%) with a median CTC count/7.5ml of 1 (range: 1-clusters with>100 epithelial cells) without significant correlations to PSA levels, pT stage, or Gleason scores. Postoperative pT stage ...Continue Reading

References

May 30, 1998·Journal of the National Cancer Institute·M W KattanP T Scardino
May 11, 1999·JAMA : the Journal of the American Medical Association·C R PoundP C Walsh
Aug 20, 2004·The New England Journal of Medicine·Massimo CristofanilliDaniel F Hayes
Feb 10, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sabine RiethdorfKlaus Pantel
Feb 21, 2008·Cancer·Nazareno SuardiPierre I Karakiewicz
Mar 20, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Shahrokh F ShariatPierre I Karakiewicz
Jul 2, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Steven J CohenNeal J Meropol
Oct 3, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Johann S de BonoDerek Raghavan
Jan 19, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jian-Mei HouCaroline Dive
Apr 18, 2012·Expert Opinion on Biological Therapy·Heidi Schwarzenbach
Jan 30, 2013·Journal of Cancer Research and Clinical Oncology·Mark ThalgottMargitta Retz
Jun 15, 2013·World Journal of Urology·Yong Mee ChoUNKNOWN Genitourinary Pathology Study Group of the Korean Society of Pathologists
Sep 4, 2013·Genome Medicine·Ellen HeitzerMichael R Speicher
Jan 9, 2014·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Mar 13, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Amir GoldkornNicholas J Vogelzang
May 17, 2014·Journal of the National Cancer Institute·Brigitte RackUNKNOWN SUCCESS Study Group
Jun 12, 2014·Current Urology·Kiranpreet K KhuranaEric A Klein
Jun 18, 2014·PloS One·Minyong KangUNKNOWN Seoul National University-Uro-Oncology Group
Jul 17, 2014·Journal of Cancer Research and Clinical Oncology·Jasmin LohJarad Martin
Aug 27, 2014·Nature Reviews. Cancer·Catherine Alix-Panabières, Klaus Pantel
Dec 3, 2014·Clinical Genitourinary Cancer·Sumanta K PalJeremy O Jones
Mar 25, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Howard I ScherJohann S de Bono

❮ Previous
Next ❯

Citations

Jul 20, 2016·BJU International·Miriam HegemannTilman Todenhöfer
Sep 23, 2016·International Journal of Molecular Sciences·Luis León-MateosLaura Muinelo Romay
Dec 8, 2016·Biomarkers in Medicine·William L HwangDavid T Miyamoto
Jun 22, 2017·Expert Review of Molecular Diagnostics·Minke SmitsJack A Schalken
Feb 28, 2018·Journal of Experimental & Clinical Cancer Research : CR·Y T LuoQ Huang
Jul 7, 2019·Cells·Lucile Broncy, Patrizia Paterlini-Bréchot
Jun 1, 2017·American Society of Clinical Oncology Educational Book·Terence W FriedlanderHimisha Beltran
Jan 4, 2019·Clinical Chemistry·Klaus PantelHoward I Scher
May 20, 2019·Radiology and Oncology·Taja LozarTanja Jesenko
Mar 17, 2017·Molecular Diagnosis & Therapy·Irene V BijnsdorpElena S Martens-Uzunova
Jan 31, 2019·Diagnostics·Jochen Neuhaus, Bo Yang
Mar 21, 2018·ACS Applied Materials & Interfaces·Yaw Opoku-DamoahYang Ding
Mar 2, 2019·Acta Cytologica·Sara Abalde-CelaLorena Diéguez

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.