PMID: 2110898Apr 30, 1990Paper

Limited proteolysis of beta 2-microglobulin at Lys-58 by complement component C1s

European Journal of Biochemistry
Mogens H NissenJ E Fothergill

Abstract

We have now demonstrated that activated complement component C1s cleaves beta 2-microglobulin at the position identical to that at which beta 2-microglobulin is cleaved in serum of patients suffering from lung cancer. The main cleavage is in the disulphide loop C-terminal to Lys-58, generating a modified form of beta 2-microglobulin with a two-chain structure. The C-terminal Lys-58 in the A chain is highly susceptible to removal by a carboxypeptidase-B-like activity causing the formation of des-Lys58-beta 2-microglobulin. This is the first demonstration of a noncomplement protein substrate for the proteolytic activity of C1s. The C1s-induced cleavage of beta 2-microglobulin can be inhibited in the presence of C1 esterase inhibitor, demonstrating a regulatory function of C1 esterase inhibitor in the C1s-induced cleavage of beta 2-microglobulin.

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Citations

May 15, 1995·Clinica Chimica Acta; International Journal of Clinical Chemistry·T MomoiA Saito
Sep 19, 2002·Protein Science : a Publication of the Protein Society·Maria MontiPiero Pucci
Sep 9, 2010·Journal of Proteome Research·Olgica TrenchevskaDobrin Nedelkov
Sep 1, 1990·Scandinavian Journal of Immunology·O W BjerrumN Borregaard
Aug 23, 2005·Biochimica Et Biophysica Acta·Niels H H Heegaard, Ersilia De Lorenzi
Aug 7, 2009·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·Niels H H Heegaard
Jul 30, 1990·FEBS Letters·K YamaguchiS Sakiyama
May 14, 2005·Clinical Chemistry·Dorthe B CorlinNiels H H Heegaard
Jan 22, 2002·The Journal of Biological Chemistry·Niels H H HeegaardMogens H Nissen
Jul 15, 1994·International Journal of Cancer. Journal International Du Cancer·N SakaiH Sakiyama
Jun 22, 2001·The Journal of Biological Chemistry·N H HeegaardM H Nissen
Jun 10, 2017·Frontiers in Immunology·Jinhua Lu, Uday Kishore
May 3, 2019·The British Journal of Dermatology·P RiihiläV-M Kähäri

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