Limited restoration of visual function after partial optic nerve injury; a time course study using the calcium channel blocker lomerizine

Brain Research Bulletin
Marion SeltMelinda Fitzgerald

Abstract

Secondary degeneration is a process encompassing damage adjacent to a primary injury, usually involving increased Ca(2+) influx into neurons and glia. Lomerizine dihydrochloride is a calcium channel blocker with relatively selective CNS effects, currently in clinical trials for glaucoma. We have recently demonstrated that, following partial transection of the optic nerve (ON), 1 month of lomerizine treatment protects retinal ganglion cells (RGCs), incompletely preserves visual function and also limits elements of secondary degeneration, including macrophage infiltration. However, under some circumstances macrophages have been shown to have different supportive effects on RGC protection and regeneration, casting doubt on the benefit of longer term therapies that reduce macrophage numbers. Here, we determined whether shorter treatment times (1 day or 1 week) result in improved effects on RGC survival and visual function, and whether benefits are maintained after cessation of treatment. We demonstrate that 1 month of lomerizine is the minimum period required to restore the fast reset phase of the optokinetic nystagmus and maintain it for a further 2 months after cessation of treatment (p>0.05, not different from normal). While 1 w...Continue Reading

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Citations

Sep 11, 2014·Neural Regeneration Research·Melinda Fitzgerald
Jul 7, 2015·Experimental Eye Research·Stephanie L Grillo, Peter Koulen
Oct 16, 2015·Assay and Drug Development Technologies·Susanne DienerBettina Lorenz-Depiereux
Apr 15, 2011·International Journal of Molecular Imaging·Joe AoyagiYasuo Iwasaki
Dec 8, 2017·Frontiers in Neuroscience·Leanne T Y CheungKin Chiu
Jul 13, 2019·Developmental Neurobiology·George G BastakisMaria Savvaki
Mar 6, 2021·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Narjes ShahsavaniSoheila Karimi-Abdolrezaee
Oct 16, 2010·Current Opinion in Ophthalmology

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