PMID: 9537866Apr 16, 1998Paper

Limited T cell receptor Vbeta-chain repertoire of liver-infiltrating T cells in autoimmune hepatitis

Journal of Hepatology
M ArenzH F Löhr

Abstract

To characterize the cellular immune reactions in autoimmune hepatitis, the T cell receptor repertoire of liver-infiltrating and circulating T cells was studied. Nucleic acids of liver-tissue and peripheral blood-derived T cells from 12 patients with untreated autoimmune hepatitis, four patients with chronic hepatitis C and three patients with toxic liver injury were extracted and analysed using a semiquantitative RT-PCR with a panel of T cell receptor Vbeta family specific primers. After agarose gel electrophoresis, the distribution of T cell receptor (TCR) Vbeta molecules was assessed by densitometry. Furthermore, results were compared to the TCR Vbeta distribution of 10 healthy blood donors. Four of 12 patients with untreated autoimmune hepatitis but no patients with chronic hepatitis C and toxic liver injury showed a significant overexpression of TCR Vbeta3 (17.8% +/- 2.6% vs. 9.3% +/- 4.6%; p = 0.01) and three an overexpression of Vbeta13.1 (14.6% +/- 2.3% vs. 6.6% +/- 3.5%; p = 0.02) molecules compared to the TCR Vbeta-distribution in healthy blood donors. In addition, Vbeta3+ T cells were found enriched in the liver tissue compared to autologous peripheral blood in three autoimmune hepatitis patients (15.3% +/- 7.0% vs. 5...Continue Reading

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Citations

Jul 2, 2005·Autoimmunity Reviews·Yasunori IchikiM Eric Gershwin
Oct 20, 1999·Human Immunology·K YoshizawaK Kiyosawa
Jan 10, 2003·Journal of Gastroenterology and Hepatology·De-Kai Qiu, Xiong Ma
Jul 11, 2000·Clinical and Experimental Immunology·T UmemuraK Kiyosawa
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Oct 7, 2006·Current Opinion in Gastroenterology·A J Czaja

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