PMID: 2125400Jan 1, 1990Paper

Limited transfer of prostaglandin E2 across the fetal membrane before and after labor

Acta Obstetricia Et Gynecologica Scandinavica
C K RosebladeM G Elder

Abstract

The transfer of prostaglandin E2 (PGE2) across intact fetal membranes (amnion-chorion-decidua) obtained before and after the onset of labor was investigated using a novel system for in vitro fetal membrane culture. Studies using physiological concentrations of PGE2 showed that very little PGE2 will cross the membranes without being metabolised, before or after the onset of labor. It was only when pharmacological concentrations of PGE2 were used that the enzyme activity of the chorion was no longer able to prevent transfer of PGE2 without conversion to inactive metabolites. These results suggest that only small amounts of PGE2 from amnion are normally transferred across the chorio-decidua before or after the onset of labor, but the metabolism of PGE2 subsequent to transfer across the fetal membranes requires further assessment.

Citations

Feb 12, 1992·Biochimica Et Biophysica Acta·M H SullivanM G Elder
Aug 1, 1994·Prostaglandins·M Y SunM G Elder
Mar 1, 1993·Baillière's Clinical Obstetrics and Gynaecology·P Bennett, N Fisk
Oct 12, 2010·Biology of Reproduction·Vasso TerzidouPhillip R Bennett
Nov 1, 1992·British Journal of Obstetrics and Gynaecology·C MorrisM G Elder
Jan 1, 1992·British Journal of Obstetrics and Gynaecology·H KhanM G Elder
Jul 1, 1991·British Journal of Obstetrics and Gynaecology·H KhanM G Elder
Dec 1, 2006·Fetal Diagnosis and Therapy·Francesco PominiSalvatore Mancuso
Sep 29, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jeffrey A KeelanMurray D Mitchell
Aug 14, 2020·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Alison J EastmanDavid M Aronoff

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