PMID: 11324887Apr 28, 2001Paper

Limited use of cyclosporin A in skeletal muscle ischemia--reperfusion injury

Annals of Plastic Surgery
A MowlaviM Neumeister

Abstract

Reperfusion injury is propagated by an inflammatory-mediated tissue edema and damage after reestablishment of vascular flow following an initial ischemic insult. In the field of transplantation, cyclosporin A(CsA) provides protection against chronic graft rejection through lymphocyte immunosuppression. Evidence for an independent protective effect of CsA against ischemia-reperfusion (IR) injury during organ transfer has prompted studies showing the benefit of CsA in various ischemia-exposed visceral organs. The authors hypothesized that CsA administration may similarly benefit IR injury after skeletal muscle amputations. To determine the effects of CsA on IR injury the authors induced 4 hours of ischemia on the gracilis muscle in a rat model. CsA (15 mg per kilogram orally) was administered in two experimental groups: (1) preischemic (N = 6): 48, 24, and 3 hours before ischemia; and (2) postischemic (N = 6): 30 minutes after induction of ischemia. The effects of CsA on IR muscle injury were observed in each of the experimental groups as well as a control group (N = 6) exposed to similar ischemia and administered a saline vehicle. Muscle viability (nitro blue tetrazolium staining) and muscle edema (wet-to-dry weight ratio) were ...Continue Reading

References

Oct 1, 1992·British Journal of Plastic Surgery·A Kucukcelebi, M Ozcan
Feb 1, 1992·Archives of Surgery·R S PoggettiA Banerjee
Feb 1, 1992·Transplantation·T KurokawaH Takagi
Jan 1, 1986·Annual Review of Pharmacology and Toxicology·B R Lucchesi, K M Mullane
Oct 1, 1972·Journal of Clinical Pathology·R Freeman, B King
May 1, 1983·Transplantation·R L Janco, D English
Mar 1, 1984·Infection and Immunity·D L WeinbaumK K Schroeder
Nov 30, 1993·Annals of the New York Academy of Sciences·G WiederrechtN Sigal
Dec 1, 1993·Journal of Molecular and Cellular Cardiology·E J Griffiths, A P Halestrap
Oct 1, 1994·American Journal of Respiratory Cell and Molecular Biology·T S BlackwellJ W Christman
Jan 1, 1993·Microsurgery·C L Kerrigan, M A Stotland
Jan 1, 1996·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·F SquadritoA P Caputi
Oct 1, 1996·The Journal of Surgical Research·R N PuglisiT V Whalen
Apr 16, 1998·Molecular and Cellular Biochemistry·D C GuteR J Korthuis
Jul 9, 1998·The Journal of Surgical Research·D L TravisM F Levy

❮ Previous
Next ❯

Citations

Feb 18, 2011·Expert Opinion on Emerging Drugs·Stefan M Gehrig, Gordon S Lynch
Sep 29, 2011·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Ismail KüçükerSühan Ayhan
Nov 16, 2011·The Journal of Hand Surgery, European Volume·D Q D Phan, F Schuind
Sep 30, 2010·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Hede YanMichael Angel
Mar 30, 2013·Journal of Applied Physiology·Maria L Urso

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.