PMID: 2492322Feb 1, 1989Paper

Limited usefulness of intermittent nitroglycerin patches in stable angina

Journal of the American College of Cardiology
D D WatersM Brien

Abstract

The efficacy of continuous and intermittent nitroglycerin patches (10 mg/day) was compared in a randomized, placebo-controlled trial in 36 patients with stable angina and reproducible, exercise-induced ST depression. Intermittent treatment was administered either 18 or 14 h/day with an intermission of 6 h or 10 h, respectively. Exercise tests were performed during the last 2 h of patch application. Compared with placebo, neither continuous nitroglycerin nor the two intermittent regimens prolonged total treadmill time or time to 1 mm ST depression. No treatment eliminated exercise-induced ST depression in greater than 1 of the 36 patients. Time to angina was prolonged (by 40 +/- 66 s) only during the "10 h off" treatment (p = 0.001); time to angina increased by greater than or equal to 20% in 13 patients. Responders to treatment could be predicted by a short history of angina (p less than 0.05) and a time to angina less than or equal to 250 s during the placebo test. For each treatment, greater than or equal to 25 of the patients reported headache; 4 additional patients dropped out because of severe headache and 2 others because of a coronary event in a washout period. Thus, in most patients with stable angina, side effects outw...Continue Reading

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Citations

Mar 1, 1996·Cardiovascular Drugs and Therapy·T O Klemsdal, K Gjesdal
Aug 1, 1994·Cardiovascular Drugs and Therapy·U Thadani, R J Lipicky
Feb 1, 1989·Journal of the American College of Cardiology·C R Conti
Feb 1, 1993·Journal of the American College of Cardiology·E RossettiS L Chierchia
Dec 29, 2000·Journal of the American College of Cardiology·D Hébert, J Y Lam
Oct 1, 1990·Journal of the American College of Cardiology·M Packer
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Oct 1, 1990·Australian and New Zealand Journal of Medicine·D W Whalley, K J Hellestrand
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Feb 27, 2007·Circulation Journal : Official Journal of the Japanese Circulation Society·Sunao KojimaUNKNOWN Japanese Acute Coronary Syndrome Study (JACSS) Investigators
Oct 20, 2004·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Ken KanamasaUNKNOWN Secondary Prevention Group
Feb 8, 2007·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Hideki MoriiKen Kanamasa
Nov 15, 1992·The American Journal of Cardiology·A W Hamer
Sep 24, 1992·The American Journal of Cardiology·U Thadani
Jun 15, 1994·International Journal of Cardiology·M Ferratini
Dec 1, 1993·The American Journal of Cardiology·S G ChrysantR Casareto
Oct 1, 1991·The American Journal of Cardiology·P A de MillianoA van de Bos
Jan 1, 1991·Postgraduate Medicine·K A Anderson

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