Limited utilities of N-terminal pro B-type natriuretic peptide and other newer risk markers compared with traditional risk factors for prediction of significant angiographic lesions in stable coronary artery disease

Heart
A PeerJ Mair

Abstract

To investigate the usefulness of N-terminal pro-brain natriuretic peptide (NT-proBNP) as a predictive marker for angiographically significant coronary artery disease (CAD) and CAD severity compared with other newer biochemical risk markers and classic risk factors in patients with clinically suspected CAD. Cross-sectional evaluation of NT-proBNP in a large consecutive series of patients without a history of myocardial infarction referred for elective coronary angiography (CAG) between March 2004 and January 2005. The value of NT-proBNP for predicting CAD was assessed and compared with high sensitivity C-reactive protein (hs-CRP), gamma-glutamyltransferase (GGT) and traditional risk factors. Tertiary care centre, Department of Cardiology, Innsbruck Medical University, Austria. 561 men and 287 women aged between 20-86 years (median 65 years). None. Association of NT-proBNP with the severity of CAD, left ventricular dysfunction and comparison of predictive values of NT-proBNP, hs-CRP, GGT and traditional CAD risk factors. Of all tested newer biochemical risk markers NT-proBNP performed best. In a multinomial logistic regression model NT-proBNP but not hs-CRP or GGT was significantly associated with three-vessel CAD adjusted for ag...Continue Reading

Citations

Aug 18, 2009·Clinical Cardiology·Harsimran S SinghMary A Whooley
Nov 27, 2010·Scandinavian Journal of Clinical and Laboratory Investigation·Marina J HarutyunyanUNKNOWN CLARICOR Trial Group
Nov 21, 2017·The American Journal of Pathology·Saranya RaviJonathan C Schisler

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