PMID: 18716379Aug 22, 2008Paper

Limited validity of o-cresol and benzylmercapturic acid in urine as biomarkers of occupational exposure to toluene at low levels

Industrial Health
O InoueM Ikeda

Abstract

This study was initiated to evaluate o-cresol and benzylmercapturic acid in urine in comparison with other biomarkers, as tools to estimate the intensity of occupational exposure to toluene at low levels. In total, 108 solvent exposed workers (engaged in tape production) and 17 non-exposed controls (all men) participated in the study. The surveys were conducted in the second half of working weeks. Diffusive sampling was conducted to measure 8-h time-weighted average intensity of occupational exposure to toluene. Blood and urine samples were collected at the end of a working shift. Blood samples were subjected to analysis for toluene (Tol-B), and urine samples were analyzed for benzyl alcohol (BeOH-U), benzylmercapturic acid (BMA-U), o-cresol (o-CR-U), hippuric acid (HA-U) and toluene (Tol-U) by the methods previously described. The toluene concentrations in workplaces were low in general, with a geometric mean (GM) and the maximum concentration of 1.9 ppm and 8.8 ppm, respectively. The statistical analyses of the six biomarkers for correlation with air-borne toluene showed that both Tol-B and Tol-U gave a high correlation coefficient of 0.58 to 0.61 (p<0.01), whereas the coefficients for BeOH-U and BMA-U together with HA-U were...Continue Reading

References

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Feb 8, 2007·Industrial Health·Toshio KawaiMasayuki Ikeda
Jul 27, 2007·International Archives of Occupational and Environmental Health·Hirohiko UkaiMasayuki Ikeda
Oct 16, 2007·International Archives of Occupational and Environmental Health·Toshio KawaiMasayuki Ikeda

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Citations

Apr 5, 2016·International Journal of Environmental Research and Public Health·Elizabeth Barksdale BoyleMichael Dellarco
Sep 11, 2013·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Frédéric CosnierPierre Campo
Jan 3, 2013·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Frédéric CosnierAurélie Rémy
Nov 7, 2016·Environmental Toxicology and Pharmacology·Alberto Thalison SilveiraIsarita Martins

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