Limited value of 18F-F-DOPA PET to localize pancreatic insulin-secreting tumors in adults with hyperinsulinemic hypoglycemia

The Journal of Clinical Endocrinology and Metabolism
L TessonnierD Taïeb

Abstract

Fluorine-18-L-dihydroxyphenylalanine positron emission tomography (18F-FDOPA PET) imaging is increasingly used in the workup of neuroendocrine tumors. It has been shown to be an accurate tool in the diagnosis of congenital hyperinsulinism, but limited information is available on its value in adult disease. OBJECTIVE, PATIENTS, AND DESIGN: The objective of this study was to review our experience with 18F-FDOPA PET imaging in six consecutive patients with hyperinsulinemic hypoglycemia (HH) (four solitary insulinomas, one diffuse beta-cell hyperplasia, one malignant insulinoma). 18F-FDOPA uptake was also evaluated in 37 patients (43 procedures) without HH or other pancreatic neuroendocrine tumors, which acted as a control group. Using visual analysis, 18F-FDOPA-PET proved positive in only one case (a multiple endocrine neoplasia type 1 related insulinoma). In diffuse beta-cell hyperplasia, the pancreatic uptake was similar to controls. In the patient with liver metastases, the extent of disease was underestimated. The pancreatic uptake was not statistically different between controls and hyperinsulinemic patients. The main limitation for identifying insulinomas or beta-cell hyperplasia in adults appears to be to the 18F-FDOPA upta...Continue Reading

Citations

Feb 19, 2013·European Journal of Nuclear Medicine and Molecular Imaging·Sona BalogovaFrançoise Montravers
Oct 17, 2013·Nuclear Medicine Communications·Sotirios ChondrogiannisDomenico Rubello
Jun 30, 2012·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Edmond RustAlessio Imperiale
Jul 19, 2011·Case Reports in Medicine·Gian Paolo FadiniAngelo Avogaro
Apr 23, 2013·European Journal of Pediatrics·Tiziana Gozzi GrafDagmar l'Allemand
Mar 7, 2014·European Journal of Endocrinology·Raja PadidelaKhalid Hussain
Mar 17, 2012·Abdominal Imaging·Vittoria RufiniAlessandro Giordano
Jul 18, 2014·PET Clinics·Sotirios ChondrogiannisDomenico Rubello
Mar 15, 2016·Best Practice & Research. Clinical Endocrinology & Metabolism·Tobias BaumannDamian Wild
Jun 26, 2013·Annales d'endocrinologie·David TaiebUNKNOWN French Endocrine Society
Jan 29, 2013·Annales d'endocrinologie·Fatima LoudaAhmed Farouqi
Jun 28, 2011·Critical Reviews in Oncology/hematology·Helle-Brit FiebrichElisabeth G E de Vries
Dec 21, 2010·Seminars in Oncology·Jorge A Carrasquillo, Clara C Chen
Nov 26, 2010·Endocrinology and Metabolism Clinics of North America·Emanuel ChristJean Claude Reubi
Nov 19, 2015·Journal of Endocrinological Investigation·J MoreraY Reznik
Jul 25, 2014·Clinical Endocrinology·Prasanna Santhanam, David Taïeb
Jun 25, 2015·BioMed Research International·Alan R PenheiterStephanie K Carlson
Oct 27, 2014·Digestive Diseases and Sciences·Gaya SpolveratoTimothy M Pawlik
Nov 5, 2014·European Journal of Nuclear Medicine and Molecular Imaging·Alessio ImperialeDavid Taïeb
May 3, 2012·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Mary E PattersonJennifer K Yee
Jun 4, 2016·International Journal of Surgery Case Reports·Vasin VasikasinSumeth Termmathurapoj
Sep 19, 2016·Abdominal Radiology·Sampanna Jung RayamajhiPriya Bhosale
Apr 13, 2017·Endocrine-related Cancer·David A Pattison, Rodney J Hicks
Jan 9, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Benjamin Leroy-FreschiniAlessio Imperiale
May 1, 2012·Expert Review of Endocrinology & Metabolism·Cornelis Jm LipsJo Wm Höppener
Nov 20, 2013·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Sandi-Jo Galati, Elliot J Rayfield
Apr 5, 2014·Journal of Paediatrics and Child Health·Kung-Ting KaoJustin Brown
Aug 24, 2012·Current Opinion in Oncology·Camilo GarciaPatrick Flamen
May 27, 2017·European Journal of Nuclear Medicine and Molecular Imaging·Murat Fani BozkurtStefano Fanti
Feb 5, 2013·Clinical Nuclear Medicine·Giorgio TregliaVittoria Rufini
Nov 1, 2010·Expert Review of Endocrinology & Metabolism·Karsten MüssigMarius Horger
Sep 1, 2014·Expert Review of Endocrinology & Metabolism·Françoise MontraversPascale de Lonlay
Dec 28, 2016·European Journal of Nuclear Medicine and Molecular Imaging·Andreas JodalMartin Béhé
May 21, 2019·Clinical Nuclear Medicine·Apurva SoodAnish Bhattacharya
Feb 17, 2021·PET Clinics·Yaping Luo, Xiaoyuan Chen
Sep 10, 2016·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Julien DetourAlessio Imperiale
Jul 3, 2010·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Damian WildHelmut R Mäcke
Dec 18, 2013·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Alessio ImperialeDavid Taïeb
Jul 13, 2021·Frontiers in Endocrinology·Takaaki MurakamiNobuya Inagaki
Aug 6, 2019·Advanced Drug Delivery Reviews·Weijun WeiWeibo Cai

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adenoma, Islet Cell

Islet Cell Adenoma arises in the islet cells, which are insulin producing cells of the pancreas. These tumors can be either malignant or benign. Discover the latest research on Islet Cell Adenoma here.

Related Papers

Best Practice & Research. Clinical Endocrinology & Metabolism
A SundinH Orlefors
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Klaas P KoopmansElisabeth G E de Vries
Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Michael GabrielIrene J Virgolini
© 2022 Meta ULC. All rights reserved