Limiting dilution analysis of proliferating and cytotoxic lymphocytes in the peripheral blood and tumours of oral cancer patients

European Journal of Cancer. Part B, Oral Oncology
A LaadS Chiplunkar

Abstract

Frequencies of proliferating and cytotoxic lymphocytes from the peripheral blood and tumour tissue of oral cancer patients and healthy individuals were monitored using limiting dilution analysis. Significantly lower precursor frequencies of proliferating lymphocytes were observed in the peripheral blood and tumour tissue of oral cancer patients. A high frequency of natural killer (NK) cells but low cytotoxic T lymphocytes (CTL) was observed in the peripheral blood compartment of oral cancer patients as compared to healthy individuals. A marked reduction in both NK and CTL frequencies in the tumour tissue compared to the peripheral blood was observed. In the tumour tissues, increased percentages of activated CD4+ lymphocytes as compared to CD8+ lymphocytes were observed. Our results suggest that impaired proliferative and cytotoxic potential of tumour infiltrating lymphocytes may play an important role in the escape of tumour cells from the immune system.

References

Jul 30, 1992·International Journal of Cancer. Journal International Du Cancer·P WangE Klein
Feb 1, 1991·International Journal of Cancer. Journal International Du Cancer·L FerradiniT Tursz
Jul 1, 1989·Head & Neck·C H SnydermanJ T Johnson
Sep 1, 1988·European Journal of Immunology·S C MeuerK H Meyer zum Büschenfelde
Jan 1, 1986·Cancer Immunology, Immunotherapy : CII·T L WhitesideV von Fliedner
Jun 15, 1986·International Journal of Cancer. Journal International Du Cancer·T L WhitesideV von Fliedner
Oct 1, 1973·European Journal of Immunology·M H JuliusL A Herzenberg
Jul 1, 1993·European Journal of Cancer. Part B, Oral Oncology·T VijayakumarD M Vasudevan
Jan 1, 1993·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·D VitoloT L Whiteside

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Citations

Jul 8, 2010·International Journal of Oral and Maxillofacial Surgery·J J LeeJ H Jeng
Aug 12, 2010·Immunopharmacology and Immunotoxicology·Chia-Chi WangTong-Rong Jan
Nov 24, 2006·Journal of Dental Research·A JewettN A Cacalano
Mar 27, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·C C WangT R Jan
Mar 21, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Loui Thomas MadakamutilVipin Kumar

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