Limiting dilution analysis of T cell unresponsiveness to mycobacteria in advanced disseminated tuberculosis

Medical Microbiology and Immunology
M S Gilardini MontaniV Colizzi

Abstract

Peripheral blood mononuclear cells from patients with advanced disseminated tuberculosis (Dis-TB) do not respond to purified protein derivative (PPD) measured as cell proliferation, lymphokine production and interleukin (IL)-2 receptor (Tac antigen) expression. Limiting dilution analysis revealed "multi-hit" curves and low frequencies of PPD-reactive T cells in cultures of Dis-TB, and "single-hit" curves and high frequencies of PPD-reactive T cells in cultures of patients with localized form of pulmonary tuberculosis. Moreover, a strict relationship between Tac antigen expression and ability of exogenous IL-2 to enhance bulk culture cell proliferation was observed in Dis-TB patients.

References

Jul 1, 1978·European Journal of Immunology·M H van OersW P Zeijlemaker
May 1, 1986·The Journal of Experimental Medicine·Z ToossiJ J Ellner
Jul 1, 1986·The Journal of Experimental Medicine·S H KaufmannG De Libero
Sep 1, 1985·The Journal of Experimental Medicine·G KaplanZ A Cohn
Aug 1, 1983·Cellular Immunology·K T PearlsteinJ Vilcek
Oct 1, 1982·The Australian Journal of Experimental Biology and Medical Science·I D MarshallK Clarke

❮ Previous
Next ❯

Citations

Dec 1, 1992·World Journal of Microbiology & Biotechnology·G Falcone

❮ Previous
Next ❯

Related Concepts

Related Feeds