Limiting feeding to the active phase reduces blood pressure without the necessity of caloric reduction or fat mass loss

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
I CôtéP J Scarpace

Abstract

Reducing body weight has been shown to lower blood pressure in obesity-related hypertension. However, success of those lifestyle interventions is limited due to poor long-term compliance. Emerging evidence indicates that feeding schedule plays a role on the regulation of blood pressure. With two studies, we examined the role of feeding schedule on energy homeostasis and blood pressure. In study 1, rats were fed a high-fat diet (HFD) ad libitum for 24 h (Control) or for 12 h during the dark phase (time-restricted feeding, TRF). In study 2, rats fed a HFD were administered a long-acting α-MSH analog at either light onset [melanotan II (MTII) light] or dark onset (MTII dark) or saline (Control). MTII light animals ate most of their calories during the active phase, similar to the TRF group. In study 1, Control and TRF rats consumed the same amount of food and gained the same amount of weight and fat mass. Interestingly, systolic and mean arterial pressure (MAP) was lower in the TRF group. In study 2, food intake was significantly lower in both MTII groups relative to Control. Although timing of injection affected light versus dark phase food consumption, neither body weight nor fat mass differed between MTII groups. Consistent wit...Continue Reading

References

Apr 15, 1978·Lancet·M W Millar-CraigE B Raftery
Oct 31, 2001·The American Journal of Clinical Nutrition·J W AndersonC L Wood
Jul 10, 2003·JAMA : the Journal of the American Medical Association·Ihab Hajjar, Theodore A Kotchen
Apr 8, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Kevin P Davy, John E Hall
Feb 8, 2007·The American Journal of Clinical Nutrition·Steven B HeymsfieldAngelo Pietrobelli
Jun 21, 2007·International Journal of Obesity : Journal of the International Association for the Study of Obesity·S L CollesP E O'Brien
Aug 7, 2007·Physiology & Behavior·Mikael AltunBrun Ulfhake
Nov 7, 2007·Cell Metabolism·Akira KohsakaJoseph Bass
Jul 4, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·M K JudgeP J Scarpace
Jul 22, 2009·The Journal of Clinical Investigation·Nicholas WallingfordSabrina Diano
Sep 5, 2009·Obesity·Deanna M ArbleFred W Turek
Dec 3, 2010·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Yuhei Kawano
Jan 19, 2011·Scandinavian Journal of Work, Environment & Health·Alwin van DrongelenAllard J van der Beek
Feb 8, 2011·Lancet·Mariel M FinucaneUNKNOWN Global Burden of Metabolic Risk Factors of Chronic Diseases Collaborating Group (Body Mass Index)
Jan 21, 2015·Journal of Internal Medicine·C Dibner, U Schibler
Feb 11, 2015·Molecular and Cellular Endocrinology·Pawan Kumar JhaAndries Kalsbeek
Mar 15, 2015·Science·Shubhroz GillSatchidananda Panda
May 21, 2015·Diabetology & Metabolic Syndrome·Maria Carlota Borba BrumTiciana C Rodrigues
Jun 27, 2015·British Journal of Pharmacology·Michael J CurtisJohn C McGrath
Sep 15, 2015·PloS One·Katrina L BraneckyJulie S Pendergast
Sep 17, 2015·Nutrition Reviews·Grant M Tinsley, Paul M La Bounty
Jan 16, 2016·The Journal of Clinical Endocrinology and Metabolism·Christopher J MorrisFrank A J L Scheer
Jun 17, 2016·Chronobiology International·Michael H SmolenskyFrancesco Portaluppi
Aug 27, 2016·The European Journal of Neuroscience·Anne-Loes OpperhuizenAndries Kalsbeek
Sep 10, 2016·Eating Behaviors·Katherine Schaumberg, Drew Anderson
Mar 16, 2017·The Journal of Physiology·Girish C Melkani, Satchidananda Panda

❮ Previous
Next ❯

Methods Mentioned

BETA
nuclear magnetic resonance

Software Mentioned

CODA

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.