Limiting habenular hyperactivity ameliorates maternal separation-driven depressive-like symptoms

Nature Communications
Anna TchenioManuel Mameli

Abstract

Early-life stress, including maternal separation (MS), increases the vulnerability to develop mood disorders later in life, but the underlying mechanisms remain elusive. We report that MS promotes depressive-like symptoms in mice at a mature stage of life. Along with this behavioral phenotype, MS drives reduction of GABAB-GIRK signaling and the subsequent lateral habenula (LHb) hyperexcitability-an anatomical substrate devoted to aversive encoding. Attenuating LHb hyperactivity using chemogenetic tools and deep-brain stimulation ameliorates MS depressive-like symptoms. This provides insights on mechanisms and strategies to alleviate stress-dependent affective behaviors.

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Citations

Aug 18, 2018·The European Journal of Neuroscience·Dorine TanFrank J Meye
Mar 13, 2019·The European Journal of Neuroscience·Mauro CongiuSalvatore Lecca
Jun 4, 2019·Proceedings of the National Academy of Sciences of the United States of America·Steven J ShabelRoberto Malinow
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Dec 5, 2019·Current Psychiatry Reports·Aiste LengvenytePhilippe Courtet
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Jan 17, 2020·Proceedings of the National Academy of Sciences of the United States of America·Matthew E KleinRoberto Malinow
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Jun 30, 2019·The Proceedings of the Nutrition Society·Marion Rincel, Muriel Darnaudéry
Jun 25, 2019·Frontiers in Psychiatry·Philip W Gold, Bashkim Kadriu
Aug 8, 2018·Frontiers in Neuroscience·Alvaro Nuno-PerezSalvatore Lecca
Sep 11, 2020·International Journal of Molecular Sciences·Matas Vitkauskas, Ajay S Mathuru
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Nov 5, 2020·International Journal of Molecular Sciences·Chaya ShorJiang-Hong Ye
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Apr 19, 2021·The European Journal of Neuroscience·Jack F WebsterChristian Wozny
Jul 13, 2021·Frontiers in Behavioral Neuroscience·Young-A Lee, Yukiori Goto
Jul 21, 2021·Neuroscience Bulletin·Junqiang ZhengHan Xu
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Dec 29, 2021·The European Journal of Neuroscience·Arnaud L LaliveManuel Mameli

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