Limiting the DNA Double-Strand Break Resectosome for Genome Protection.

Trends in Biochemical Sciences
Daryl A RonatoJean-Yves Masson

Abstract

DNA double-strand break (DSB) resection, once thought to be a simple enzymatic process, is emerging as a highly complex series of coordinated activities required to maintain genome integrity. Progress in cell biology, biochemistry, and genetics has deciphered the precise resecting activities, the regulatory components, and their ability to properly channel the resected DNA to the appropriate DNA repair pathway. Herein, we review the mechanisms of regulation of DNA resection, with an emphasis on negative regulators that prevent single-strand (ss)DNA accumulation to maintain genome stability. Interest in targeting DNA resection inhibitors is emerging because their inactivation leads to poly(ADP-ribose) polymerase inhibitor (PARPi) resistance. We also present detailed regulation of DNA resection machineries, their analysis by functional assays, and their impact on disease and PARPi resistance.

Citations

Feb 10, 2021·Seminars in Cell & Developmental Biology·Laure Guitton-SertJean-Yves Masson
Feb 14, 2021·Journal of Huntington's Disease·Amit L DeshmukhChristopher E Pearson
Feb 23, 2021·DNA Repair·Wangtao ShenShuya He
Mar 16, 2021·Frontiers in Cell and Developmental Biology·Huiming Lu, Anthony J Davis
Apr 27, 2021·Trends in Genetics : TIG·Chaoyou Xue, Eric C Greene
Jun 16, 2021·Open Biology·C R MortonL Pellegrini
Jul 1, 2021·Cell Reports·Janna LuessingNoel Francis Lowndes
Sep 10, 2021·Nucleic Acids Research·Abhishek Bharadwaj SharmaEric Van Dyck
Nov 14, 2021·Nature Communications·Jenny Kaur SinghHaico van Attikum

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