Limits to sustained energy intake. XXX. Constraint or restraint? Manipulations of food supply show peak food intake in lactation is constrained.

The Journal of Experimental Biology
Zhi-Jun ZhaoJ R Speakman

Abstract

Lactating mice increase food intake 4- to 5-fold, reaching an asymptote in late lactation. A key question is whether this asymptote reflects a physiological constraint, or a maternal investment strategy (a 'restraint'). We exposed lactating mice to periods of food restriction, hypothesizing that if the limit reflected restraint, they would compensate by breaching the asymptote when refeeding. In contrast, if it was a constraint, they would by definition be unable to increase their intake on refeeding days. Using isotope methods, we found that during food restriction, the females shut down milk production, impacting offspring growth. During refeeding, food intake and milk production rose again, but not significantly above unrestricted controls. These data provide strong evidence that asymptotic intake in lactation reflects a physiological/physical constraint, rather than restraint. Because hypothalamic neuropeptide Y (Npy) was upregulated under both states of restriction, this suggests the constraint is not imposed by limits in the capacity to upregulate hunger signalling (the saturated neural capacity hypothesis). Understanding the genetic basis of the constraint will be a key future goal and will provide us additional informat...Continue Reading

References

Oct 1, 1991·The American Journal of Physiology·E M TolozaJ Diamond
Mar 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·C C PetersonJ Diamond
Apr 3, 1997·Nature·K A Hammond, J Diamond
Jul 14, 1998·Physiology & Behavior·J G MercerP Barrett
Apr 15, 2000·Nature·G S BarshS O'Rahilly
Apr 15, 2000·Nature·M W SchwartzD G Baskin
Nov 14, 2000·Physiological and Biochemical Zoology : PBZ·K A Hammond, D M Kristan
Feb 24, 2001·Endocrine Research·G BarshS Watson
May 9, 2003·Mechanisms of Ageing and Development·Brad A RikkeThomas E Johnson
Aug 1, 1960·Biological Reviews of the Cambridge Philosophical Society·P N WILSON, D F OSBOURN
Oct 29, 2003·The Journal of Experimental Biology·E Król, J R Speakman
Jul 28, 2005·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·John R Speakman, Elzbieta Król
Jan 20, 2007·The Journal of Experimental Biology·Xue-Ying Zhang, De-Hua Wang
Aug 10, 2007·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·John R Speakman
Aug 21, 2007·Physiology & Behavior·Catherine HamblyJohn R Speakman
Nov 21, 2007·The Journal of Experimental Biology·Elzbieta KrólJohn R Speakman
May 19, 2009·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Zhi-Jun Zhao, Jing Cao
Jul 28, 2009·Ageing Research Reviews·Iustin TabareanBruno Conti
Aug 4, 2009·The Journal of Experimental Biology·Zhi-Jun Zhao, Jing Cao
Mar 4, 2010·Genome Biology·Mark D Robinson, Alicia Oshlack
May 1, 2010·Physiology & Behavior·Zhi-Jun ZhaoJing Cao
May 7, 2010·The Journal of Animal Ecology·John R Speakman, Elzbieta Król
Dec 21, 2010·The Journal of Nutrition·Kerry M Cameron, John R Speakman
Dec 24, 2010·The Journal of Experimental Biology·John R Speakman, Elżbieta Król
Feb 19, 2011·Genes & Cancer·Yien Che Tsai, Allan M Weissman
Aug 16, 2011·Molecular Aspects of Medicine·John R Speakman, Sharon E Mitchell
Sep 13, 2011·Physiology & Behavior·Li-Na ZhangJohn R Speakman
Sep 29, 2011·Disease Models & Mechanisms·Catherine HamblyJohn R Speakman
Nov 26, 2011·The Journal of Experimental Biology·Elzbieta KrólJohn R Speakman
Dec 29, 2011·The Journal of Clinical Investigation·Joshua P ThalerMichael W Schwartz
May 31, 2013·The Journal of Experimental Biology·Zhi-Jun ZhaoJohn R Speakman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.