Lin28a regulates neurogliogenesis in mammalian retina through the Igf signaling

Developmental Biology
Xiaohuan XiaIqbal Ahmad

Abstract

In the developing central nervous system (CNS) the majority of neurons are born before the generation of glia. Emerging evidence implicates heterochronic gene, Lin28 in the temporal switch between two distinct lineages. However, the respective contributions of Lin28a and Lin28b in neurogliogenesis remain poorly understood. Here, we have examined the relative involvement of Lin28a and Lin28b in mammalian retina, a simple and accessible CNS model where neurogliogenic decision largely occurs postnatally. Examination of Lin28a/b involvement during late histogenesis by the perturbation of function approaches revealed that while Lin28b did not influence differentiation in general Lin28a facilitated and antagonized the generation of neurons and glia, respectively. Silencing of Lin28a expression in vitro and its conditional deletion in vivo during early histogenesis led to premature generation of glia. The instructive role of Lin28a on neuronal differentiation was revealed by its influence to suppress glial-specific genes and directly differentiate glia along the neuronal lineage. This function of Lin28a is likely mediated through the Igf signaling, as inhibition of the pathway abrogated Lin28a-mediated neurogliogenesis. Thus, our obse...Continue Reading

Citations

Apr 5, 2020·Stem Cells·Judith S KempfleAlbert S B Edge
Dec 18, 2019·Progress in Retinal and Eye Research·Iqbal AhmadXiaohuan Xia
Mar 23, 2021·Investigative Ophthalmology & Visual Science·Lorena Teixeira FrassonCarolina Beltrame Del Debbio
Mar 28, 2019·Developmental Biology·Xiaohuan XiaIqbal Ahmad
May 1, 2020·Molecular Therapy : the Journal of the American Society of Gene Therapy·Fatima M NathanShuxin Li
Mar 26, 2021·Stem Cells·Xiaohuan XiaIqbal Ahmad

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.