Lin28b promotes fetal B lymphopoiesis through the transcription factor Arid3a

The Journal of Experimental Medicine
Yan ZhouRichard R Hardy

Abstract

Mouse B cell precursors from fetal liver and adult bone marrow (BM) generate distinctive B cell progeny when transplanted into immunodeficient recipients, supporting a two-pathway model for B lymphopoiesis, fetal "B-1" and adult "B-2." Recently, Lin28b was shown to be important for the switch between fetal and adult pathways; however, neither the mechanism of Lin28b action nor the importance of B cell antigen receptor (BCR) signaling in this process was addressed. Here, we report key advances in our understanding of the regulation of B-1/B-2 development. First, modulation of Let-7 in fetal pro-B cells is sufficient to alter fetal B-1 development to produce B cells resembling the progeny of adult B-2 development. Second, intact BCR signaling is required for the generation of B1a B cells from Lin28b-transduced BM progenitors, supporting a requirement for ligand-dependent selection, as is the case for normal B1a B cells. Third, the VH repertoire of Lin28b-induced BM B1a B cells differs from that of normal B1a, suggesting persisting differences from fetal progenitors. Finally, we identify the Arid3a transcription factor as a key target of Let-7, whose ectopic expression is sufficient to induce B-1 development in adult pro-B cells a...Continue Reading

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Citations

Feb 13, 2016·Immunological Reviews·J Stewart NewJohn F Kearney
Sep 5, 2015·European Journal of Immunology·Richard R Hardy, Kyoko Hayakawa
Mar 8, 2016·Cancer Letters·Shuai Jiang, David Baltimore
Dec 24, 2015·The Journal of Experimental Medicine·Julie LangRoberta Pelanda
Apr 25, 2015·Annals of the New York Academy of Sciences·Kyoko HayakawaRichard R Hardy
May 2, 2015·Annals of the New York Academy of Sciences·Yue-Sheng LiRichard R Hardy
Apr 29, 2016·Nature Reviews. Immunology·Arnav Mehta, David Baltimore
Jun 4, 2016·Cell Stem Cell·R Grant RoweGeorge Q Daley
Jul 13, 2016·The Journal of Experimental Medicine·R Grant RoweGeorge Q Daley
Aug 23, 2016·Current Stem Cell Reports·Christine Roden, Jun Lu
Dec 8, 2016·European Journal of Immunology·Lilly von MuenchowAntonius G Rolink
Nov 8, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nicole Baumgarth
Jul 26, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xingjun LiuRichard R Hardy
Jun 15, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kyoko HayakawaRichard R Hardy
Dec 30, 2015·Molecular and Cellular Biology·Carmela CalésMiguel Vidal
Sep 8, 2017·The Journal of Experimental Medicine·Kyoko HayakawaRichard R Hardy
Jun 22, 2019·Genes & Development·Saifeng WangStefan A Muljo
Dec 19, 2019·Viral Immunology·J Stewart NewJohn F Kearney
Sep 29, 2019·Science Immunology·Stijn VanheeJoan Yuan
Feb 26, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jennifer A JacobsenBarbara L Kee
Dec 6, 2019·International Journal of Hematology·Momoko Yoshimoto
Jan 14, 2020·Annual Review of Immunology·Brian D Rudd
Apr 2, 2019·Frontiers in Immunology·Kyoko HayakawaRichard R Hardy
Feb 6, 2020·Proceedings of the National Academy of Sciences of the United States of America·Xijin XuRichard J Cornall
Mar 23, 2017·Nature Immunology·Henry H Wortis
Apr 25, 2018·Frontiers in Immunology·Chrysi Kanellopoulou, Stefan A Muljo
Jan 20, 2018·Nature Immunology·Martin Turner, Manuel D Díaz-Muñoz
Nov 16, 2018·Frontiers in Immunology·Anne-Margarete BrenneckeSiegfried Weiss
Sep 27, 2019·Cells·Joshua GartonCarol F Webb

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Methods Mentioned

BETA
flow cytometry
PCR
sumoylation
Feature Extraction
Assay
transfection
transgenic
electrophoresis

Software Mentioned

Bioconductor
R
TargetScan
Advalytix
Java
MacVector
Agilent Technologies Feature Extraction
IPA
TreeView
Ingenuity

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