LIN7A is a major determinant of cell-polarity defects in breast carcinomas

Breast Cancer Research : BCR
Nadège GruelAnne Vincent-Salomon

Abstract

Polarity defects are a hallmark of most carcinomas. Cells from invasive micropapillary carcinomas (IMPCs) of the breast are characterized by a striking cell polarity inversion and represent an interesting model for the analysis of polarity abnormalities. In-depth investigation of polarity proteins in 24 IMPCs and a gene expression profiling, comparing IMPC (n = 73) with invasive carcinomas of no special type (ICNST) (n = 51) have been performed. IMPCs showed a profound disorganization of the investigated polarity proteins and revealed major abnormalities in their subcellular localization. Gene expression profiling experiments highlighted a number of deregulated genes in the IMPCs that have a role in apico-basal polarity, adhesion and migration. LIN7A, a Crumbs-complex polarity gene, was one of the most differentially over-expressed genes in the IMPCs. Upon LIN7A over-expression, we observed hyperproliferation, invasion and a complete absence of lumen formation, revealing strong polarity defects. This study therefore shows that LIN7A has a crucial role in the polarity abnormalities associated with breast carcinogenesis.

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Jun 3, 2014·Breast Cancer Research : BCR·Nadège GruelAnne Vincent-Salomon
Oct 22, 2014·Molecular and Cellular Biology·Afnan Abu-ThuraiaJean-François Côté

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Citations

Jul 29, 2017·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Rachel L StewartErinn Downs-Kelly
Mar 18, 2021·Cancer Cell International·Simon KeaneKatarina Ejeskär

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Datasets Mentioned

BETA
GM130
GSE66418

Methods Mentioned

BETA
FCS
Chip
PCR

Software Mentioned

GC Robust Multi - array Average package
GC Robust Multi - array Average ( GCRMA )
Database for Annotation , Visualization and Integrated Discove...
Adobe Photoshop
R
DAVID

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