Linagliptin safety profile: A systematic review

Primary Care Diabetes
Gabrielle Kéfrem Alves GomesAndré Oliveira Baldoni

Abstract

To describe the safety profile of linagliptin. Systematic review using PubMed/MEDLINE, BVS and Web of Science. The search strategy "Linagliptin" AND "safety" was used. The inclusion criteria were clinical trials with a control group composed of conventional DM2 pharmacotherapy. We identified 16 studies, and the most frequent adverse events (AEs) were nasopharyngitis with linagliptin at 5 and 10mg in monotherapy (31.6% and 29.6%, respectively) and gastrointestinal events (>10.0%) with linagliptin in combination. Of the AEs, 14.9 (±3.1)% were associated with the use of linagliptin in monotherapy, and 17.6 (±6.0)% in combination. The linagliptin AEs have a varied occurrence and frequency, ranging from mild to moderate intensity.

Citations

Jun 11, 2019·Frontiers in Pharmacology·Gabrielle Kéfrem Alves GomesAndré Oliveira Baldoni

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