LINC00116 codes for a mitochondrial peptide linking respiration and lipid metabolism

Proceedings of the National Academy of Sciences of the United States of America
Anastasia ChugunovaOlga Dontsova

Abstract

Genes coding for small peptides have been frequently misannotated as long noncoding RNA (lncRNA) genes. Here we have demonstrated that one such transcript is translated into a 56-amino-acid-long peptide conserved in chordates, corroborating the work published while this manuscript was under review. The Mtln peptide could be detected in mitochondria of mouse cell lines and tissues. In line with its mitochondrial localization, lack of the Mtln decreases the activity of mitochondrial respiratory chain complex I. Unlike the integral components and assembly factors of NADH:ubiquinone oxidoreductase, Mtln does not alter its enzymatic activity directly. Interaction of Mtln with NADH-dependent cytochrome b5 reductase stimulates complex I functioning most likely by providing a favorable lipid composition of the membrane. Study of Mtln illuminates the importance of small peptides, whose genes might frequently be misannotated as lncRNAs, for the control of vitally important cellular processes.

References

Sep 1, 1977·Journal of Steroid Biochemistry·V V Reddy, E Caspi
Jul 12, 1972·Biochimica Et Biophysica Acta·P G Passon, D E Hultquist
Apr 3, 2004·Genome Research·Mathieu BlanchetteWebb Miller
Nov 2, 2005·Molecular and Cellular Biology·Christopher E EllisRobert L Nussbaum
Jul 25, 2006·Current Biology : CB·Heidi M McBrideSylwia Wasiak
Aug 4, 2006·Molecular Cell·B Matija Peterlin, David H Price
Jan 31, 2007·Annals of Neurology·Daniel Fernandez-MoreiraJoaquín Arenas
May 19, 2007·Science·Philipp KapranovThomas R Gingeras
Jun 3, 2008·American Journal of Human Genetics·Saskia J G HoefsLambert P van den Heuvel
Sep 26, 2013·Biochemical Society Transactions·Marion Babot, Alexander Galkin
Oct 26, 2013·Nature Protocols·F Ann RanFeng Zhang
Nov 5, 2013·Nucleic Acids Research·Audrey M MichelPavel V Baranov
Dec 10, 2013·Developmental Cell·Serene C ChngBruno Reversade
Jan 11, 2014·Science·Andrea PauliAlexander F Schier
Feb 12, 2014·Nature Reviews. Genetics·Shea J Andrews, Joseph A Rothnagel
Feb 25, 2014·Biochimica Et Biophysica Acta·Marion BabotAlexander Galkin
May 28, 2014·Methods in Enzymology·Aleksandra WojtalaMariusz R Wieckowski
Aug 28, 2014·Cell Reports·Nicholas T IngoliaJonathan S Weissman
Jan 3, 2015·Nature Reviews. Genetics·Daniel Holoch, Danesh Moazed
Feb 5, 2015·Biotechnology Journal·Eric KowarzRolf Marschalek
Mar 5, 2015·Cell Metabolism·Kim Zarse, Michael Ristow
Apr 15, 2015·Trends in Genetics : TIG·Georges St LaurentPhilipp Kapranov
Aug 21, 2015·Aging Cell·Noriyuki FukuNobuyoshi Hirose
Sep 18, 2015·PloS One·Etienne P A NeveMagnus Ingelman-Sundberg
Oct 10, 2015·Nucleic Acids Research·Sarah E CalvoVamsi K Mootha
Dec 17, 2015·Nature Reviews. Genetics·Jeffrey J Quinn, Howard Y Chang
Feb 10, 2016·Trends in Biochemical Sciences·Sara CogliatiLuca Scorrano
Jun 5, 2016·Trends in Biochemical Sciences·Jose I PueyoJuan P Couso

❮ Previous
Next ❯

Citations

Nov 25, 2019·Wiley Interdisciplinary Reviews. RNA·Stephen J KiniryPavel V Baranov
Jun 24, 2020·International Journal of Cancer. Journal International Du Cancer·Yingcheng WuRenfang Mao
Mar 18, 2020·Frontiers in Genetics·Mirjana Gusic, Holger Prokisch
Aug 14, 2020·Journal of Cellular Biochemistry·Yingzhou ShiYueliang Shen
Mar 3, 2020·Frontiers in Cell and Developmental Biology·Julie MartoneMonica Ballarino
Dec 25, 2019·Signal Transduction and Targeted Therapy·Shuo WangShanrong Liu
Mar 11, 2020·Proceedings of the National Academy of Sciences of the United States of America·Mikhail Y VyssokikhVladimir P Skulachev
Feb 11, 2020·Frontiers in Cell and Developmental Biology·Zhen DongHongjuan Cui
Oct 17, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Agata KodrońAgnieszka Chacińska
Nov 17, 2020·Frontiers in Genetics·Diego Guerra-Almeida, Rodrigo Nunes-da-Fonseca
Oct 23, 2020·Cancer Cell International·Mujie YeKuiran Dong
Feb 2, 2021·Frontiers in Oncology·Jiani XingLihong Wang
Feb 1, 2020·Redox Biology·Carolyn M Klinge
Feb 18, 2021·The FEBS Journal·Dörte Schlesinger, Simon J Elsässer
Apr 4, 2020·Stem Cell Reports·Max FriesenChad A Cowan
Aug 15, 2021·Current Opinion in Plant Biology·Robert H Calderon, Åsa Strand
Aug 28, 2021·International Journal of Molecular Sciences·Daria KoninaMikhail Skoblov
Sep 8, 2021·Frontiers in Cell and Developmental Biology·Oza ZaheedKellie Dean
Sep 4, 2021·Molecular Therapy : the Journal of the American Society of Gene Therapy·Man-Huan XiaoJian-Hong Fang
Dec 11, 2021·Frontiers in Oncology·Yao ChenJing Shen

❮ Previous
Next ❯

Methods Mentioned

BETA
FACS
Immunoprecipitation

Software Mentioned

ELABELA
DWORF

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Nihon rinsho. Japanese journal of clinical medicine
Toshiaki Miki
Nihon rinsho. Japanese journal of clinical medicine
M Takeshita, K Shirabe
© 2022 Meta ULC. All rights reserved