LINC00152 promotes the growth and invasion of oral squamous cell carcinoma by regulating miR-139-5p.

OncoTargets and Therapy
Minghe LiLei Wang

Abstract

LINC00152 plays a crucial role in tumorigenesis and progression of multiple types of cancer. However, the biological significance of LINC00152 and its potential role in oral squamous cell carcinoma (OSCC) remain to be determined. In the present study, we investigated the role of LINC00152 and the underlying mechanism of its oncogenic activity in OSCC. The expression of LINC00152 in OSCC tissues and cell lines was detected using qRT-PCR. Cell proliferation, colony formation, migration, and invasion were measured using a cell counting kit, colony formation assay, wound healing, and transwell invasion assays, respectively. The target gene of LINC00152 was confirmed using a dual-luciferase reporter assay and qRT-PCR. A nude mouse model was established to analyze the function of LINC00152 in vivo. LINC00152 expression was significantly upregulated in OSCC tissues and cell lines compared with that in normal counterparts. Upregulated LINC00152 served as an independent prognostic predictor in patients with OSCC. Moreover, knockdown of LINC00152 inhibited cell proliferation, colony formation, migration, and invasion, and suppressed the epithelial to mesenchymal transition in vitro, as well as impairing tumor growth in vivo. A mechanisti...Continue Reading

Citations

Mar 7, 2020·Journal of Zhejiang University. Science. B·Hong Yu, Shu-Bin Li
Jun 5, 2020·Cellular Oncology (Dordrecht)·Fei HuangQianming Chen
Feb 2, 2021·Frontiers in Oncology·Yuming XuZhengjun Shang
Dec 10, 2019·Experimental and Molecular Pathology·Soudeh Ghafouri-FardMohammad Taheri
Jun 3, 2021·International Journal of Molecular Sciences·Cing-Syuan LeiJing-Wen Shih

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Methods Mentioned

BETA
Protein Assay
transfection
Assay
xenograft

Software Mentioned

miRanda
NIH ImageJ
GraphPad
GraphPad Prism
Starbase
SPSS

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