LINC00174 is an oncogenic lncRNA of hepatocellular carcinoma and regulates miR-320/S100A10 axis.

Cell Biochemistry and Function
Jin-Tao ZhaoYong Xia

Abstract

Hepatocellular carcinoma (HCC) is one of the deadliest cancers. Multiple long non-coding RNAs (lncRNAs) are recently identified as crucial oncogenic factors or tumour suppressors. In this study, we explored the effects of LINC00174 on the progression of HCC. Expression levels of LINC00174 and microRNA-320 (miR-320) in HCC tissue samples were measured using quantitative real-time polymerase chain reaction (qRT-PCR). The association between pathological indices and LINC00174 was also analysed. Human HCC cell lines Hep3B and Huh7 were used as cell models. CCK-8 and bromodeoxyuridine (BrdU) assays were used to assess the effect of LINC00174 on HCC cell line proliferation. Flow cytometry was used to study the effect of LINC00174 on HCC apoptosis. Transwell assay was conducted to detect the effect of LINC00174 on migration and invasion. Furthermore, luciferase reporter assay and RNA immunoprecipitation (RIP) assay were used to confirm the binding relationship between miR-320 and LINC00174. Additionally, western blot was used to detect the regulatory function of LINC00174 on oncogene S100 calcium binding protein A10 (S100A10). We demonstrated that LINC00174 expression in HCC clinical samples was significantly increased and this was co...Continue Reading

References

Dec 19, 2009·International Journal of Cancer. Journal International Du Cancer·Rie WadaYasuhito Yuasa
Apr 20, 2013·International Journal of Molecular Sciences·Xiangxiang ShanFen Zhou
Jul 6, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jinfu ShangShaofan Qiu
May 20, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Hashem B El-Serag, Fasiha Kanwal
Mar 10, 2015·Clinics and Research in Hepatology and Gastroenterology·Song HeCheng Wei
Jun 18, 2016·International Journal of Molecular Sciences·Ewelina PerdasMaria Zubrzycka
Nov 18, 2016·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Yan PanLongbang Chen
Jun 14, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Xiance JinCongying Xie
Jun 16, 2017·Liver International : Official Journal of the International Association for the Study of the Liver·Huaqiang ZhuJun Lu
Sep 1, 2017·Molecular Cancer·Galina KhemlinaRazelle Kurzrock
Sep 25, 2017·Biological Research·Cuicui PanYueran Zhao
Oct 5, 2017·Cancer Control : Journal of the Moffitt Cancer Center·Richard A Burkhart, Timothy M Pawlik
Oct 5, 2017·Cancer Control : Journal of the Moffitt Cancer Center·Jennifer EatridesRichard Kim
Feb 20, 2018·Molecular and Cellular Biochemistry·Nearmeen M RashadSalem Y Mohamed
Jul 12, 2018·World Journal of Gastroenterology : WJG·Francesco VasuriDario de Biase
Jul 17, 2018·Molecular Oncology·Moamen BydounDavid M Waisman
Nov 6, 2018·Journal of Cellular and Molecular Medicine·Chao WangQiang You
May 17, 2019·Anticancer Research·Maria V ChristensenEstrid Høgdall

❮ Previous
Next ❯

Citations

Dec 11, 2020·BioMed Research International·Mohamed H YousefAnwar Abdelnaser
Jul 28, 2021·Biochemical and Biophysical Research Communications·Pan LiuHongwei Zhang
Jul 7, 2021·Journal of Microbiology and Biotechnology·Yuhong MaXiaofei Li
Jun 4, 2021·Canadian Journal of Physiology and Pharmacology·Juan-Juan WangDing-Ding Wang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.