LINC00341 exerts an anti-inflammatory effect on endothelial cells by repressing VCAM1

Physiological Genomics
Tse-Shun HuangShu Chien

Abstract

The long noncoding RNAs (lncRNAs), which constitute a large portion of the transcriptome, have gained intense research interest because of their roles in regulating physiological and pathophysiological functions in the cell. We identified from RNA-Seq profiling a set of lncRNAs in cultured human umbilical vein endothelial cells (HUVECs) that are differentially regulated by atheroprotective vs. atheroprone shear flows. Among the comprehensively annotated lncRNAs, including both known and novel transcripts, LINC00341 is one of the most abundant lncRNAs in endothelial cells. Moreover, its expression level is enhanced by atheroprotective pulsatile shear flow and atorvastatin. Overexpression of LINC00341 suppresses the expression of vascular cell adhesion molecule 1 (VCAM1) and the adhesion of monocytes induced by atheroprone flow and tumor necrosis factor-alpha. Underlying this anti-inflammatory role, LINC00341 guides enhancer of zest homolog 2, a core histone methyltransferase of polycomb repressive complex 2, to the promoter region of the VCAM1 gene to suppress VCAM1. Network analysis reveals that the key signaling pathways (e.g., Rho and PI3K/AKT) are co-regulated with LINC00341 in endothelial cells in response to pulsatile shea...Continue Reading

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Citations

Feb 3, 2018·Journal of Cellular and Molecular Medicine·Zhongju ShiShiqing Feng
Jul 10, 2018·Journal of Translational Internal Medicine·Liang Bai, John Y-J Shyy
Apr 13, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Haochuan LiuQingsan Zhu
Jun 6, 2018·Frontiers in Physiology·Tyler WeirickShizuka Uchida
Oct 4, 2017·Frontiers in Pharmacology·Suowen Xu
Dec 26, 2018·Proceedings of the National Academy of Sciences of the United States of America·Qing LyuJoseph M Miano
Feb 26, 2020·APL Bioengineering·Ming HeBrendan Gongol
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Jan 21, 2021·Proceedings of the National Academy of Sciences of the United States of America·Mano R MauryaShankar Subramaniam
Mar 2, 2021·Frontiers in Cell and Developmental Biology·Chih-Hung LaiZhen Bouman Chen
Apr 2, 2021·Oxidative Medicine and Cellular Longevity·Zijian ZhouDong Wang
Oct 3, 2020·Cancer Letters·Yunqiu Zhang, Zhonghan Li
May 26, 2021·Journal of Neuroscience Research·Xiaoping TanShuyan Cong
Aug 14, 2021·Experimental Cell Research·Furong LuYiming Shao

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Datasets Mentioned

BETA
GSE71164

Methods Mentioned

BETA
fluorescence microscopy
HTseq
RNA-IP
RIP
PCR
Assay
RNA-Seq

Software Mentioned

HTseq
UCSC genome browser
Cufflinks
Gencode
Reactome FIViz
Cytoscape ReactomeFIViz
DESeq2
Tophat2
Ensembl

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