Linc00483 as ceRNA regulates proliferation and apoptosis through activating MAPKs in gastric cancer.

Journal of Cellular and Molecular Medicine
Defeng LiYuqiang Nie

Abstract

Long non-coding RNAs (lncRNAs) are important regulators of many cellular processes, and their aberrant expression and/or function is associated with many different diseases, including cancer. However, the identification of functional lncRNAs in gastric cancer is still a challenge. In this study, we describe a novel functional lncRNA, linc00483, that is upregulated and associated with tumorigenesis, tumour size, metastasis and poor prognosis in gastric cancer. In our study, linc00483 promoted gastric cancer cell proliferation, invasiveness and metastasis in vitro and in vivo. Mechanistically, upregulated expression of linc00483 in gastric cancer acts as a sponge to absorb endogenous tumour suppressor miR-30a-3p. Furthermore, it restores SPAG9 expression, which is negatively regulated by miR-30a-3p, and actives MAPK signaling pathway in gastric cancer cells. Thus, linc00483 is an oncogenic lncRNA in gastric cancer and targeting linc00483 or its pathway can potentially be useful in development of targeted therapies for patients with gastric cancer. Our results show that linc00483 is an important regulator in carcinogenesis and may be a useful biomarker to predict prognosis of gastric cancer patients. We believe our findings are no...Continue Reading

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Citations

Jan 12, 2019·Human Gene Therapy. Clinical Development·Liang HanXudong Wu
May 6, 2019·Journal of Cellular Biochemistry·Jinhui LiuWenjun Cheng
Jul 5, 2019·Journal of Cellular Biochemistry·Ganxun LiZeyang Ding
Sep 10, 2020·International Journal of Molecular Sciences·Hiroki ShimomuraNaohiko Seki
Jul 20, 2019·Cancer Biomarkers : Section a of Disease Markers·Yi LiZhenjun Liu
Feb 23, 2019·World Journal of Gastrointestinal Oncology·Cheng ZhangDong-Qiu Dai
Jan 1, 2020·Cellular & Molecular Biology Letters·Shengzhuang YangXiangsen Liang
Mar 29, 2020·Journal of Computational Biology : a Journal of Computational Molecular Cell Biology·Xin ChangDe-Feng Li
Apr 25, 2020·International Journal of Molecular Sciences·Lucia MagnelliLaura Papucci
May 6, 2020·OncoTargets and Therapy·Xue LengFangzhou Song
Jan 6, 2021·Journal of Experimental & Clinical Cancer Research : CR·Jiacheng CaoZekuan Xu
Jul 27, 2021·Frontiers in Pharmacology·Laeza Alves SampaioAdriana Gibara Guimarães

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Datasets Mentioned

BETA
BGC823

Methods Mentioned

BETA
Transfection
xenograft
xenografts

Software Mentioned

ArrayStar
SPSS

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