Abstract
Long non-coding RNAs (lncRNAs) are important regulators of many cellular processes, and their aberrant expression and/or function is associated with many different diseases, including cancer. However, the identification of functional lncRNAs in gastric cancer is still a challenge. In this study, we describe a novel functional lncRNA, linc00483, that is upregulated and associated with tumorigenesis, tumour size, metastasis and poor prognosis in gastric cancer. In our study, linc00483 promoted gastric cancer cell proliferation, invasiveness and metastasis in vitro and in vivo. Mechanistically, upregulated expression of linc00483 in gastric cancer acts as a sponge to absorb endogenous tumour suppressor miR-30a-3p. Furthermore, it restores SPAG9 expression, which is negatively regulated by miR-30a-3p, and actives MAPK signaling pathway in gastric cancer cells. Thus, linc00483 is an oncogenic lncRNA in gastric cancer and targeting linc00483 or its pathway can potentially be useful in development of targeted therapies for patients with gastric cancer. Our results show that linc00483 is an important regulator in carcinogenesis and may be a useful biomarker to predict prognosis of gastric cancer patients. We believe our findings are no...Continue Reading
References
Aug 4, 2005·The Keio Journal of Medicine·Nirmala JagadishAnil Suri
May 15, 2007·Oncogene·D N DhanasekaranE P Reddy
May 19, 2007·Science·Philipp KapranovThomas R Gingeras
Oct 17, 2008·Cancer Research·Manoj GargAnil Suri
Jun 15, 2010·Molecular Cell·Kyoko L YapMing-Ming Zhou
Jul 1, 2010·RNA·Hui JiaLeonard Lipovich
Aug 2, 2011·Cell·Leonardo SalmenaPier Paolo Pandolfi
Dec 3, 2013·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·W WangS Zheng
Apr 29, 2014·Cancer Cell·Ji-hang YuanShu-han Sun
Oct 4, 2014·Cancer Research·Ye HuJing-Yuan Fang
Dec 6, 2014·Cell Death & Disease·J TangB Sun
Dec 11, 2014·Journal of Hematology & Oncology·Gregory LoewenBin Shan
Feb 3, 2015·Molecular Carcinogenesis·Wenting PanMing Yang
Feb 6, 2015·CA: a Cancer Journal for Clinicians·Lindsey A TorreAhmedin Jemal
Sep 19, 2015·Oncotarget·Mulong DuZhengdong Zhang
Oct 4, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Benli WangXiaodong Liu
Dec 23, 2015·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Hisato Kawakami, Isamu Okamoto
Feb 13, 2016·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·M Martin-RichardA Carrato
Feb 13, 2016·Oncotarget·Mitsuro KandaYasuhiro Kodera
Feb 20, 2016·Journal of Gastroenterology·Takeshi YamadaIchisnosuke Hyodo
Feb 20, 2016·Oncology Letters·D I WuGuangmei Zhang
Feb 24, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Pei MaYongqian Shu
Feb 26, 2016·Molecular Cancer Therapeutics·Li WanZhao-Xia Wang
Mar 2, 2016·Neoplasma·C L YuanY Shu
Mar 31, 2016·IUBMB Life·Wei DengZhongtao Zhang
Apr 5, 2016·OncoTargets and Therapy·Tong LiuChuan-Xin Wang
May 6, 2016·Cancer Discovery·Tian-Tian SunJing-Yuan Fang
Oct 23, 2016·Oncotarget·Yongfu ShaoJunming Guo
Jul 15, 2016·Pathology Oncology Research : POR·Jian ChenQinshi Pan
Jul 16, 2016·Oncotarget·Rony K RoyAnand D Jeyasekharan
Jul 28, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Zhi-Yuan FanMin Yan
Jul 30, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Shifeng ChenChengming Sun
Citations
Jun 14, 2018·Human Gene Therapy·Chi ChiWenjie Hou
Jan 12, 2019·Human Gene Therapy. Clinical Development·Liang HanXudong Wu
Oct 27, 2018·Journal of Cellular Physiology·Xiaoli KongQifeng Yang
Feb 26, 2019·Carcinogenesis·Congcong GongJiaoyan Ren
May 6, 2019·Journal of Cellular Biochemistry·Jinhui LiuWenjun Cheng
Jul 5, 2019·Journal of Cellular Biochemistry·Ganxun LiZeyang Ding
Apr 16, 2020·Biological Research·Min Luo, Chengbai Liang
May 21, 2020·Scientific Reports·Sepideh DashtiMohammad Taheri
Jun 20, 2020·Journal of Cellular Physiology·Lina WangQianfei Zuo
Nov 16, 2018·Frontiers in Endocrinology·Linna SuoYuyan Zhao
Sep 14, 2019·FEBS Open Bio·Yongyun LuoAirong Tan
Sep 10, 2020·International Journal of Molecular Sciences·Hiroki ShimomuraNaohiko Seki
Jul 20, 2019·Cancer Biomarkers : Section a of Disease Markers·Yi LiZhenjun Liu
Feb 23, 2019·World Journal of Gastrointestinal Oncology·Cheng ZhangDong-Qiu Dai
Jul 3, 2019·Frontiers in Endocrinology·Linna SuoHongmei Ji
Jan 1, 2020·Cellular & Molecular Biology Letters·Shengzhuang YangXiangsen Liang
Mar 29, 2020·Journal of Computational Biology : a Journal of Computational Molecular Cell Biology·Xin ChangDe-Feng Li
Apr 25, 2020·International Journal of Molecular Sciences·Lucia MagnelliLaura Papucci
Oct 23, 2019·Journal of Cellular Physiology·Li FengZhen Yang
May 6, 2020·OncoTargets and Therapy·Xue LengFangzhou Song
Aug 28, 2019·Journal of Cellular Biochemistry·Jie WangXiaxia Wang
Aug 28, 2019·Life Sciences·Pin HuYunxia Cao
Jan 24, 2021·Cell Death & Disease·Jianheng WuFuyong Li
Jan 6, 2021·Journal of Experimental & Clinical Cancer Research : CR·Jiacheng CaoZekuan Xu
Oct 23, 2020·Cancer Cell International·Xufeng Guo, Ming Li
Dec 31, 2020·Cancers·Hung Ho-XuanChristina Hackl
Feb 9, 2021·Frontiers in Oncology·Duilia BrexMarco Ragusa
Jun 8, 2021·Cell Cycle·Jianwen LiuGuangshao Cao
Jul 27, 2021·Frontiers in Pharmacology·Laeza Alves SampaioAdriana Gibara Guimarães
Aug 17, 2021·Oxidative Medicine and Cellular Longevity·De-Feng LiJun Yao
Nov 25, 2021·Experimental and Therapeutic Medicine·Feng HuYanfang Jiang