LINC00662 Promotes Oral Squamous Cell Carcinoma Cell Growth and Metastasis through miR-144-3p/EZH2 Axis.

Yonsei Medical Journal
Yongmei YaoZhaohua Meng

Abstract

Long non-coding RNA (lncRNA) is identified as an important regulator involved in oral squamous cell carcinoma (OSCC) tumorigenesis. This study aimed to investigate the functional role and underlying mechanism of LINC00662 in OSCC. The expression levels of LINC00662, miR-144-3p, and enhancer of zeste homolog 2 (EZH2) mRNA were quantified with quantitative real-time polymerase chain reaction in OSCC tissues and cell lines. Western blot analysis was used to assay the expression levels of E-cadherin, Vimentin, and EZH2. Cell proliferation, migration, and invasion were monitored by cell counting kit-8 and Transwell assays. Dual-luciferase reporter and RNA immunoprecipitation assays were employed to verify the regulatory relationship between LINC00662 and miR-144-3p. The expression of LINC00662, positively associated with the increased TNM stage and lymph node metastasis of the patients, was up-regulated in OSCC tissues and cells. The overexpression of LINC00662 facilitated the proliferation, migration, and invasion of OSCC cells. MiR-144-3p could bind to LINC00662, and the promoting effect of LINC00662 overexpression was counteracted by miR-144-3p mimic. Moreover, EZH2 expression was negatively regulated by miR-144-3p and positively...Continue Reading

References

Jun 13, 2009·Endocrinology·William G NelsonSrinivasan Yegnasubramanian
Mar 30, 2010·Trends in Biochemical Sciences·Lluís Morey, Kristian Helin
May 21, 2013·Molecular and Cellular Endocrinology·Woo Kyun Bae, Lothar Hennighausen
Dec 4, 2013·Nature Reviews. Genetics·Alessandro Fatica, Irene Bozzoni
Jul 29, 2015·CA: a Cancer Journal for Clinicians·Angela C ChiBrad W Neville
Mar 24, 2016·Cellular and Molecular Life Sciences : CMLS·Sandra U SchmitzBernhard G Herrmann
Jun 18, 2016·Cancer Discovery·Haikuo ZhangKwok-Kin Wong
Sep 14, 2017·International Journal of Oncology·Jiaqing CaoXiaolin Li
Oct 27, 2017·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Wen XiaoXiaoping Zhang
Mar 1, 2018·Journal of Translational Medicine·Alexander W EckertBarbara Seliger
Oct 10, 2018·Biochemical and Biophysical Research Communications·Zhen LiuJun Deng
Dec 14, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jingyi SongNingning He
Apr 7, 2019·Pathology, Research and Practice·Jiewei XuGuochao Ye
Aug 2, 2019·Journal of Cellular and Molecular Medicine·Min ZhengXin-Hua Liang
Oct 8, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Wenjie HuangXuxia Peng
Dec 20, 2019·Biotechnology and Applied Biochemistry·Lilong XiaJing Luo

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