LINC01915 Facilitates the Conversion of Normal Fibroblasts into Cancer-Associated Fibroblasts Induced by Colorectal Cancer-Derived Extracellular Vesicles through the miR-92a-3p/KLF4/CH25H Axis.

ACS Biomaterials Science & Engineering
Minghe ZhouJiapeng Zhou


Increasing long non-coding RNAs are reported to regulate the cell growth, apoptosis, and metastasis of cancer-associated fibroblasts (CAFs).This study aimed to explore how LINC01915 influences the conversion of normal fibroblasts (NFs) into CAFs in colorectal cancer (CRC). LINC01915 expression was initially measured in clinical tissue samples and in NFs and CAFs. Identification of the interaction between LINC01915, miR-92a-3p, KLF4, and CH25H was done. The effects of LINC01915, miR-92a-3p, and KLF4 on the angiogenesis, extracellular vesicle (EV) uptake by NFs, and activation of stromal cells were assessed using gain- or loss-of-function approaches. Xenograft mouse models were established to validate these in vitro findings in vivo. EVs were shown to stimulate NF proliferation, migration, and angiogenesis, as well as facilitate NF conversion into CAFs. CRC tissues and CAFs showed downregulated expression of LINC01915, which was associated with poor prognosis of patients. Moreover, employed LINC01915 inhibited tumor angiogenesis, CAF activation, and the uptake of tumor-derived EVs by NFs. Mechanistically, LINC01915 could competitively bind to miR-92a-3p and caused upregulation of the miR-92a-3p target KLF4 which, in turn, promote...Continue Reading


Aug 4, 2012·Cell Death and Differentiation·M-L VolvertL Nguyen
Aug 3, 2013·Translational Oncology·Nami YamadaYukihiro Akao
Mar 5, 2016·Brazilian Journal of Cardiovascular Surgery·Shi-Min Yuan
Jul 1, 2017·Angiogenesis·Claire Viallard, Bruno Larrivée
Dec 1, 2017·European Journal of Medical Research·Ya-Nan WangWei-Chang Chen
Jun 26, 2018·International Journal of Colorectal Disease·Venu Gopala Reddy GangireddySamip Parikh
Aug 22, 2018·Molecular Therapy. Nucleic Acids·Asghar ArshiMohammad Mahdi Ghahramani Seno
Dec 16, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yan DongChong-Yao Bi
Jan 5, 2019·Angiogenesis·Chikage NoishikiShigetomo Fukuhara
Mar 5, 2019·Current Medicinal Chemistry·Narges DastmalchiMirsaed Miri Nargesi
Aug 6, 2019·European Review for Medical and Pharmacological Sciences·P-J LiuX-B Fang
Dec 6, 2019·Biochemical and Biophysical Research Communications·Beixin YuZhao Li
May 21, 2020·European Review for Medical and Pharmacological Sciences·T-L Zheng, K Cen
Jan 1, 2019·Journal of Cancer Metastasis and Treatment·Kimberley C AgboVincent W Yang
Oct 13, 2020·Cell Cycle·Zijian YeChong Wang
Dec 31, 2020·International Journal of Molecular Sciences·Ahmed MalkiAla-Eddin Al Moustafa
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