Linchpin dienes: key building-blocks in the synthesis of polyenic frameworks

Organic & Biomolecular Chemistry
Johan CornilJanine Cossy

Abstract

A myriad of biologically active products incorporates polyenic frameworks. Among the syntheses developed to access these moieties, metal-catalyzed cross-couplings emerged as reactions of choice especially due to their high stereoselectivity. Particularly, the use of bifunctionalized compounds (linchpin reagents) allows a fast, modular and efficient access to polyenic chains. In this review, we will focus on the preparation of bifunctionalized dienes and on their utilization in the synthesis of polyenes.

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Citations

Jan 13, 2016·The Journal of Organic Chemistry·Rajendra Shivaji Mane, Bhalchandra M Bhanage
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