PMID: 7524595May 1, 1994Paper

Lindane affects phosphoinositide turnover through a different mechanism of the phosphatidylinositol synthesis inhibition in rat renal proximal tubule cell culture

Cellular Signalling
S SenarM A Pérez-Albarsanz

Abstract

The ability of lindane to change the metabolism of inositol phospholipids was investigated using rat renal proximal tubular cell cultures labelled with [3H]inositol. Lindane addition to the culture medium caused labelling of inositol trisphosphate, inositol bisphosphate and inositol tetrakisphosphate to decrease and that of the inositol monophosphate pool to increase. A depletion of radioactivity in phosphatidylinositols was also observed after lindane addition. Most strikingly, the addition of lindane considerably increased the levels of glycerophosphoinositol in a dose-dependent manner. The effect of lindane follows a different pattern from that of bradykinin, and it is suggested to act by stimulating phospholipase A activity(ies).

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Citations

Jun 19, 2002·Biochimica Et Biophysica Acta·Daniela CordaChristopher P Berrie
Mar 21, 2001·Cellular Signalling·M F SantiagoM A Pérez-Albarsanz
Apr 12, 2007·Journal of Biochemical and Molecular Toxicology·Mercedes Fernández SantiagoMiguel A Pérez-Albarsanz
Oct 12, 2013·The Journal of Biological Chemistry·Andrew C BishopJana Patton-Vogt
Mar 4, 2000·Chemico-biological Interactions·E SánchezM A Pérez-Albarsanz

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