LINE-1 distribution in Afrotheria and Xenarthra: implications for understanding the evolution of LINE-1 in eutherian genomes

Chromosoma
Paul D WatersT J Robinson

Abstract

Long interspersed nuclear elements (LINEs) comprise about 21% of the human genome (of which L1 is most abundant) and are preferentially accumulated in AT-rich regions, as well as the X and Y chromosomes. Most knowledge of L1 distribution in mammals is restricted to human and mouse. Here we report the first investigation of L1 distribution in the genomes of a wide variety of eutherian mammals, including species in the two basal clades, Afrotheria and Xenarthra. Our results show L1 accumulation on the X of all eutherian mammals, an observation consistent with an ancestral involvement of these elements in the X-inactivation process (the Lyon repeat hypothesis). Surprisingly, conspicuous accumulation of L1 in AT-rich regions of the genome was not observed in any species outside of Euarchontoglires (represented by human, mouse and rabbit). Although several features were common to most species investigated, our comprehensive survey shows that the patterns observed in human and mouse are, in many aspects, far from typical for all mammals. We discuss these findings with reference to models that have previously been proposed to explain the AT distribution bias of L1 in human and mouse, and how this relates to the evolution of these elem...Continue Reading

Citations

Jul 3, 2007·Chromosoma·Paul D WatersTerence J Robinson
Oct 20, 2005·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·G DobignyT J Robinson
Feb 11, 2005·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Gauthier DobignyVitaly Volobouev
Sep 12, 2006·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·J L DeuveT J Robinson
Feb 3, 2009·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Paola RebuzziniSilvia Garagna
Apr 3, 2010·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Philippe GauthierGauthier Dobigny
Aug 19, 2011·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Daleen BadenhorstTerence J Robinson
Sep 27, 2012·Genetica·Heidi L BonifácioEliana Feldberg
Aug 30, 2005·Annual Review of Genomics and Human Genetics·Jennifer C ChowCarolyn J Brown
Jan 18, 2007·PloS One·Paul D WatersTerence J Robinson
Jul 16, 2009·PloS One·Michael A CantrellHolly A Wichman
Jan 19, 2008·Genetics·Michael A CantrellHolly A Wichman
Jun 27, 2014·PLoS Genetics·Lei YangHolly Wichman
Oct 7, 2008·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·M J AcostaA Sánchez
Aug 24, 2007·Micron : the International Research and Review Journal for Microscopy·Susana MelesRaquel Chaves
Apr 3, 2007·Seminars in Cell & Developmental Biology·Paul D WatersJennifer A Marshall Graves
Dec 30, 2014·BMC Evolutionary Biology·Claudia L Rodríguez-DelgadoPaul D Waters
Feb 18, 2006·Cytogenetic and Genome Research·L A ScottH A Wichman
Jun 9, 2012·Cytogenetic and Genome Research·M Svartman
Aug 12, 2014·Journal of Applied Genetics·Ana PaçoRaquel Chaves
May 30, 2019·Mobile DNA·Lei YangHolly A Wichman
Mar 29, 2016·Journal of Genetics·A Vieira-da-SilvaR Chaves
Nov 9, 2017·Comparative Cytogenetics·Érica Martinha Silva de SouzaEliana Feldberg
Sep 17, 2017·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Cibele Gomes de Sotero-CaioNeide Santos

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