LINE-1 methylation is positively associated with healthier lifestyle but inversely related to body fat mass in healthy young individuals

Epigenetics : Official Journal of the DNA Methylation Society
José Luiz Marques-RochaJosefina Bressan

Abstract

With the goal of investigating if epigenetic biomarkers from white blood cells (WBC) are associated with dietary, anthropometric, metabolic, inflammatory and oxidative stress parameters in young and apparently healthy individuals. We evaluated 156 individuals (91 women, 65 men; age: 23.1±3.5 years; body mass index: 22.0±2.9 kg/m(2)) for anthropometric, biochemical and clinical markers, including some components of the antioxidant defense system and inflammatory response. DNA methylation of LINE-1, TNF-α and IL-6 and the expression of some genes related to the inflammatory process were analyzed in WBC. Adiposity was lower among individuals with higher LINE-1 methylation. On the contrary, body fat-free mass was higher among those with higher LINE-1 methylation. Individuals with higher LINE-1 methylation had higher daily intakes of calories, iron and riboflavin. However, those individuals who presented lower percentages of LINE-1 methylation reported higher intakes of copper, niacin and thiamin. Interestingly, the group with higher LINE-1 methylation had a lower percentage of current smokers and more individuals practicing sports. On the other hand, TNF-α methylation percentage was negatively associated with waist girth, waist-to-...Continue Reading

References

Apr 1, 1997·The American Journal of Clinical Nutrition·W C WillettL H Kushi
Sep 19, 2000·Medicine and Science in Sports and Exercise·B E AinsworthA S Leon
Apr 18, 2001·Journal of Pediatric Endocrinology & Metabolism : JPEM·L A MorenoM Bueno
May 14, 2004·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Iñigo Navarro-Blasco, J I Alvarez-Galindo
Feb 11, 2005·Clinical and Experimental Hypertension : CHE·Judith A Whitworth, John Chalmers
Sep 2, 2005·Nature Reviews. Genetics·Keith D Robertson
Dec 6, 2005·Nucleic Acids Research·Daniel J WeisenbergerPeter W Laird
Feb 24, 2006·Nature Reviews. Cancer·Stephen B Baylin, Joyce E Ohm
Sep 9, 2006·The American Journal of Clinical Nutrition·Julia WärnbergUNKNOWN AVENA Study Group
Mar 17, 2007·Nature Reviews. Genetics·Randy L Jirtle, Michael K Skinner
Oct 1, 2009·Nature Reviews. Genetics·Peter A Jones, Gangning Liang
Mar 20, 2010·PloS One·Myungjin KimPeter W Laird
Sep 18, 2010·International Journal of Epidemiology·Zhong-Zheng ZhuAndrea Baccarelli
Oct 6, 2010·Advances in Genetics·Marta Kulis, Manel Esteller
Apr 5, 2011·American Journal of Human Genetics·Lutz P BreitlingHermann Brenner
Apr 6, 2011·Journal of Physiology and Biochemistry·Paul CorderoJ Alfredo Martinez
Apr 29, 2011·The Journal of Nutrition·Fang Fang ZhangRoberto Cardarelli
Jun 4, 2011·Epigenetics : Official Journal of the DNA Methylation Society·Mary Beth TerryRegina M Santella
Jun 18, 2011·Medicine and Science in Sports and Exercise·Barbara E AinsworthArthur S Leon
Jul 12, 2011·Epigenetics : Official Journal of the DNA Methylation Society·Fang Fang ZhangAlfredo Morabia
Sep 20, 2011·Cell·Nidhi BhutaniHelen M Blau
Nov 30, 2011·The Proceedings of the Nutrition Society·Paula Dominguez-SalasSophie E Moore
Mar 12, 2013·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Alexandra J WhiteLisa A DeRoo
Apr 5, 2013·Environmental Health Perspectives·Salman M TajuddinUNKNOWN Spanish Bladder Cancer/EPICURO Study Investigators
May 7, 2013·Epigenetics : Official Journal of the DNA Methylation Society·Xiaojing XuXiaoling Wang
Jul 25, 2013·Frontiers in Genetics·Ken W K Lee, Zdenka Pausova
Jan 16, 2014·Advances in Nutrition·J Alfredo MartínezKevin L Schalinske
Jan 31, 2014·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·W PerngA V Diez-Roux
May 1, 2015·Epigenetics : Official Journal of the DNA Methylation Society·Lauren E McCulloughCathrine Hoyo
May 20, 2015·Clinical Epigenetics·Adrian Ruiz-HernandezMaria Tellez-Plaza

❮ Previous
Next ❯

Citations

May 26, 2016·Clinical Epigenetics·Claudia KnotheJörn Lötsch
May 18, 2016·Scientific Reports·Carmen de la RochaGertrud Lund
May 10, 2017·Journal of Cancer Epidemiology·Nayha Chopra-TandonSusan R Sturgeon
Feb 16, 2019·Epigenetics : Official Journal of the DNA Methylation Society·David John HunterSarabjit S Mastana
Mar 14, 2019·Journal of the American College of Nutrition·Lílian L LopesHelen Hermana M Hermsdorff
Jul 30, 2020·Medicina·Andrea Maugeri, Martina Barchitta
Sep 18, 2020·Environmental Science and Pollution Research International·Diana Marcela Paredes-CéspedesYael Yvette Bernal-Hernández
Jun 3, 2017·International Journal of Cosmetic Science·U MagnetA G Haslberger
Feb 23, 2019·Frontiers in Genetics·Ivana Babić BožovićBojana Brajenović-Milić
Jul 12, 2018·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Devon J BoyneDarren R Brenner
May 27, 2021·Antioxidants & Redox Signaling·Amaya Lopez-PascualPedro González-Muniesa
Jun 21, 2021·International Archives of Occupational and Environmental Health·Ibrahim IssahJulius N Fobil
Jun 30, 2021·Arhiv za higijenu rada i toksikologiju·Tihana MarićAnna Aghayanian

❮ Previous
Next ❯

Datasets Mentioned

BETA
X58075

Methods Mentioned

BETA
enzyme-linked immunosorbent assay
ELISA
PCR
biopsies

Software Mentioned

GraphPad Prism®
High ReSolution Melt
SAS
DietPro®
SDS
Excel

Related Concepts

Related Feeds

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.

Cancer Epigenetics & Metabolism (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. This feed focuses on the relationship between cell metabolism, epigenetics and tumor differentiation.

Cancer Epigenetics & Methyl-CpG (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. Here is the latest research on cancer epigenetics and methyl-CpG binding proteins including ZBTB38.

Cancer Epigenetics and Senescence (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may be involved in regulating senescence in cancer cells. This feed captures the latest research on cancer epigenetics and senescence.

Cancer Epigenetics (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. Here is the latest research on cancer epigenetics.

Cancer Epigenetics

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. Here is the latest research on cancer epigenetics.

Cell Signaling & Cancer Epigenetics (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. This feed covers the latest research on signaling and epigenetics in cell growth and cancer.

© 2022 Meta ULC. All rights reserved