PMID: 30141457Aug 25, 2018Paper

Line Immunoassay: A Rapid Test for Screening TORCH Complex in Antenatal Patients with Bad Obstetric History

Mymensingh Medical Journal : MMJ
H KumarP Shinu

Abstract

TORCH {Toxoplasma gondii, Rubella, Cytomegalovirus (CMV), the Herpes Simplex Virus (HSV)} infection causes pregnancy wastage at any stage of gestation. Serological assays can be an important tool for diagnosis. It includes ELISA which is highly specific & sensitive with certain drawbacks like time consuming and for each genus separate test have to be done. Line-Immunoassay (LIA), a newer, cheaper and reliable technique on contrary is done on single panel strip. The present retrospective study was conducted with the aim to evaluate the efficacy of Line Immunoassay for detection of TORCH IgM antibodies. A total of 630 samples from the pregnant women with Bad Obstetric History (BOH) attending OPD and IPD of Obstetrics and Gynecology Department of Maharishi Markandeshwar Institute of Medical Science & Research (MMIMSR), Mullana, Ambala, Haryana, India from 2011 to 2015 were subjected to Line-Immunoassay and ELISA for detection of IgM antibodies against TORCH agents in Department of Microbiology. The analysis for TORCH complex showed 32.85% positivity by LIA while 36.03% by ELISA. The diagnostic accuracy of LIA when ELISA considered gold standard was also exhibited which showed Sensitivity of 90.75%, Specificity of 99.75% while PPV ...Continue Reading

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved